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650366 Tryptase, Human Lung

Tryptase, Human Lung MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
650366
  
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Přehled

Replacement Information
Description
OverviewNative tryptase from human lung. Tryptase is a serine protease stored in mast cell granules. A tetrameric enzyme composed of four non-covalently bound subunits. Each subunit is reported to contain one active site. Reported to upregulate neoangiogenesis in carcinogenesis of the uterine cortex. Tryptase is also an important mediator of allergic reactions that activates G-protein-coupled receptors through proteolysis, thus amplifying histamine release.
Catalogue Number650366
Brand Family Calbiochem®
References
ReferencesBenitez-Bribiesca, L., et al. 2001. J. Histochem. Cytochem. 49, 1061.
He, S., et al. 1998. J. Pharmacol. Exp. Ther. 286, 289.
Molino, M., et al. 1997. J. Biol. Chem. 272, 4043.
Schwartz, L.B., and Bradford, T.R. 1986. J. Biol. Chem. 261, 7372.
Product Information
Unit of DefinitionOne unit is defined as the amount of enzyme that gives a change of 1 absorbance per min at 410 nm using N-benzoyl-Phe-Val-Arg-<i>p</i>NA as a substrate in 30 min at 25°C.
EC number3.4.21.59
FormLiquid
FormulationIn 1 M NaCl, 50 mM NaOAc, 50 µM heparin, 0.05% NaN₃.
Quality LevelMQ100
Applications
Biological Information
SourcePrepared from tissue that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific Activity≥50 U/mg protein
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38-42/43

Irritating to eyes, respiratory system and skin.
May cause sensitization by inhalation and skin contact.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage -20°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
650366 0

Documentation

Tryptase, Human Lung MSDS

Title

Safety Data Sheet (SDS) 

Tryptase, Human Lung Certificates of Analysis

TitleLot Number
650366

References

Přehled odkazů
Benitez-Bribiesca, L., et al. 2001. J. Histochem. Cytochem. 49, 1061.
He, S., et al. 1998. J. Pharmacol. Exp. Ther. 286, 289.
Molino, M., et al. 1997. J. Biol. Chem. 272, 4043.
Schwartz, L.B., and Bradford, T.R. 1986. J. Biol. Chem. 261, 7372.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-November-2021 JSW
DescriptionNative tryptase from human lung. Tryptase is a serine protease stored in mast cell granules. A tetrameric enzyme composed of four non-covalently bound subunits. Each subunit is reported to contain one active site. Tryptase is an important mediator of allergic reactions that activates G-protein-coupled receptors through proteolysis, thus amplifying histamine release.
FormLiquid
FormulationIn 1 M NaCl, 50 mM NaOAc, 50 µM heparin, 0.05% NaN₃.
Concentration Label Please refer to vial label for lot-specific concentration
SourcePrepared from tissue that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
EC number3.4.21.59
Specific activity≥50 U/mg protein
Unit definitionOne unit is defined as the amount of enzyme that gives a change of 1 absorbance per min at 410 nm using N-benzoyl-Phe-Val-Arg-pNA as a substrate in 30 min at 25°C.
Storage Avoid freeze/thaw
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Irritant
ReferencesBenitez-Bribiesca, L., et al. 2001. J. Histochem. Cytochem. 49, 1061.
He, S., et al. 1998. J. Pharmacol. Exp. Ther. 286, 289.
Molino, M., et al. 1997. J. Biol. Chem. 272, 4043.
Schwartz, L.B., and Bradford, T.R. 1986. J. Biol. Chem. 261, 7372.