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506300 TrkB Agonist, 7,8-Dihydroxyflavone - CAS 38183-03-8 - Calbiochem

TrkB Agonist, 7,8-Dihydroxyflavone - CAS 38183-03-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7,8-DHF

Primary Target: TrkB
506300
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
38183-03-8C₁₅H₁₀O₄

Products

Katalogové čísloBalení ks/bal.
5.06300.0001 Skleněná láhev 100 mg
Description
OverviewA cell permeable flavone based compound with neurotrophic and neuroprotective properties. Mimicks the action of Brain Derived Neurotrophic Factor (BDNF) and acts as a TrkB receptor agonist. Due to its lipophilic nature, it can cross the blood-brain barrier. Binds to the extra cellular domain of TrkB with high affinity and promotes its dimerization and autophosphorylation. Potentiates TrkB, but not TrkA, signaling in mouse brain slices. Its neurotropic effects are abolished in the presence of K252a. Suppresses apoptosis in human and rodent neurons and in stably transfected TrkB murine cell line T48 (EC50 = 35 nM). Selectively reduces the basal GABAergic transmission due to its suppressive effect on presynaptic GABA release. However, it does not affect glutamatergic transmission.
Catalogue Number506300
Brand Family Calbiochem®
Synonyms7,8-DHF
References
ReferencesRen, Q., et al. 2013. Pharm. Biochem. Behav. 106, 124.
Marongiu, D., et al. 2013. Eur. J. Pharmacol. 709, 64.
Jang, S., et al. 2010. PNAS 107, 2687.
Product Information
CAS number38183-03-8
FormYellow powder
Hill FormulaC₁₅H₁₀O₄
Chemical formulaC₁₅H₁₀O₄
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetTrkB
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
5.06300.0001 04055977243222

Documentation

TrkB Agonist, 7,8-Dihydroxyflavone - CAS 38183-03-8 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Přehled odkazů
Ren, Q., et al. 2013. Pharm. Biochem. Behav. 106, 124.
Marongiu, D., et al. 2013. Eur. J. Pharmacol. 709, 64.
Jang, S., et al. 2010. PNAS 107, 2687.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-November-2013 JSW
Synonyms7,8-DHF
DescriptionA cell permeable flavone based compound with neurotrophic and neuroprotective properties. Mimicks the action of Brain Derived Neurotrophic Factor (BDNF) and acts as a TrkB receptor agonist. Due to its lipophilic nature, it can cross the blood-brain barrier. Binds to the extra cellular domain of TrkB with high affinity and promotes its dimerization and autophosphorylation. Potentiates TrkB, but not TrkA, signaling in mouse brain slices. Its neurotropic effects are abolished in the presence of K252a. Suppresses apoptosis in human and rodent neurons and in stably transfected TrkB murine cell line T48 (EC50 = 35 nM). Selectively reduces the basal GABAergic transmission due to its suppressive effect on presynaptic GABA release. However, it does not affect glutamatergic transmission.
FormYellow powder
Intert gas (Yes/No) Packaged under inert gas
CAS number38183-03-8
Chemical formulaC₁₅H₁₀O₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesRen, Q., et al. 2013. Pharm. Biochem. Behav. 106, 124.
Marongiu, D., et al. 2013. Eur. J. Pharmacol. 709, 64.
Jang, S., et al. 2010. PNAS 107, 2687.