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613560 TMPyP4 - CAS 36951-72-1 - Calbiochem

A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM).

TMPyP4 - CAS 36951-72-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: meso-5,10,15,20-Tetrakis-(N-methyl-4-pyridyl)porphine, Tetratosylate

Primary Target: human telomerase
613560
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
36951-72-1C₄₄H₃₈N₈ · C₂₈H₂₈O₁₂S₄

Products

Katalogové čísloBalení ks/bal.
613560-25MG Plastová ampulka 25 mg
Description
OverviewA potent inhibitor of human telomerase (IC50 = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces intensely in the presence of quadruplex DNA.
Catalogue Number613560
Brand Family Calbiochem®
Synonymsmeso-5,10,15,20-Tetrakis-(N-methyl-4-pyridyl)porphine, Tetratosylate
References
ReferencesYamashita, T., et al. 2005. Bioorg. Med. Chem. 13, 2433.
Izbicka, E., et al. 1999. Cancer Res. 59, 639.
Anantha, N.V., et al. 1998. Biochemistry 37, 2709.
Arthanari, H., et al. 1998. Nucleic Acids Res. 26, 3724.
Wheelhouse, R.T., et al. 1998. J. Am. Chem. Soc. 120, 3261.
Product Information
CAS number36951-72-1
ATP CompetitiveN
FormPurple solid
Hill FormulaC₄₄H₃₈N₈ · C₂₈H₂₈O₁₂S₄
Chemical formulaC₄₄H₃₈N₈ · C₂₈H₂₈O₁₂S₄
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targethuman telomerase
Primary Target IC<sub>50</sub>6.5 µM inhibiting human telomerase
Purity≥90% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
613560-25MG 04055977263541

Documentation

TMPyP4 - CAS 36951-72-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

TMPyP4 - CAS 36951-72-1 - Calbiochem Certificates of Analysis

TitleLot Number
613560

References

Přehled odkazů
Yamashita, T., et al. 2005. Bioorg. Med. Chem. 13, 2433.
Izbicka, E., et al. 1999. Cancer Res. 59, 639.
Anantha, N.V., et al. 1998. Biochemistry 37, 2709.
Arthanari, H., et al. 1998. Nucleic Acids Res. 26, 3724.
Wheelhouse, R.T., et al. 1998. J. Am. Chem. Soc. 120, 3261.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-December-2018 JSW
Synonymsmeso-5,10,15,20-Tetrakis-(N-methyl-4-pyridyl)porphine, Tetratosylate
DescriptionA potent inhibitor of human telomerase (IC50 = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces highly in the presence of quadruplex DNA.
FormPurple solid
CAS number36951-72-1
Chemical formulaC₄₄H₃₈N₈ · C₂₈H₂₈O₁₂S₄
Structure formulaStructure formula
Purity≥90% by TLC
SolubilityH₂O (1 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesYamashita, T., et al. 2005. Bioorg. Med. Chem. 13, 2433.
Izbicka, E., et al. 1999. Cancer Res. 59, 639.
Anantha, N.V., et al. 1998. Biochemistry 37, 2709.
Arthanari, H., et al. 1998. Nucleic Acids Res. 26, 3724.
Wheelhouse, R.T., et al. 1998. J. Am. Chem. Soc. 120, 3261.