Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

574662 Survivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem

The Survivin Inhibitor, YM155, also referenced under CAS 781661-94-7, controls the biological activity of Survivin.

Survivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Survivin Inhibitor I, Interleukin Enhancer-Binding Factor 3 Inhibitor

Primary Target: Interleukin enhancer-binding factor 3 (ILF3/NF110)
574662
  
Purchase on Sigma-Aldrich

Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
781661-94-7C₂₀H₁₉BrN₄O₃
Description
OverviewA cell-permeable imidazolium derivative that suppresses survivin expression, blocks survivin promoter activity, and induces apoptosis in a variety of tumor cell lines (IC50 = 540nM) in a dose-dependent manner. The main target of YM155 appears to be the interleukin enhancer-binding factor 3 (ILF3/NF110) with shorter C-terminal lengths associated with reduced binding. Exhibits potent anti-tumor effects without any severe systemic toxicity in murine models. Reported to induce tumor regression by suppressing intratumor survivin levels in PC3-xenograph tumor models (by 47% and 80% at 1 and 5 mg/kg, respectively.
Catalogue Number574662
Brand Family Calbiochem®
SynonymsSurvivin Inhibitor I, Interleukin Enhancer-Binding Factor 3 Inhibitor
References
ReferencesNakamura, N., et al. 2012. Mol. Cell. Proteomics. 11, M111.0132434.
Tolcher, A.W., et al. 2008, J. Clin. Oncol. 26, 5198.
Nakahara, T., et al. 2007, Cancer Res. 67, 8014.
Product Information
CAS number781661-94-7
FormYellow solid
Hill FormulaC₂₀H₁₉BrN₄O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target Interleukin enhancer-binding factor 3 (ILF3/NF110)
Primary Target IC<sub>50</sub>540nM
Secondary targetUnknown
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
574662 0

Documentation

Survivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Survivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem Certificates of Analysis

TitleLot Number
574662

References

Přehled odkazů
Nakamura, N., et al. 2012. Mol. Cell. Proteomics. 11, M111.0132434.
Tolcher, A.W., et al. 2008, J. Clin. Oncol. 26, 5198.
Nakahara, T., et al. 2007, Cancer Res. 67, 8014.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-March-2017 JSW
SynonymsSurvivin Inhibitor I, Interleukin Enhancer-Binding Factor 3 Inhibitor
DescriptionA cell-permeable imidazolium derivative that suppresses survivin expression, blocks survivin promoter activity, and induces apoptosis in a variety of tumor cell lines (IC50 = 540nM) in a dose-dependent manner. The main target of YM155 appears to be the interleukin enhancer-binding factor 3 (ILF3/NF110) with shorter C-terminal lengths associated with reduced binding. Exhibits potent anti-tumor effects without any severe systemic toxicity in murine models. Reported to induce tumor regression by suppressing intratumor survivin levels in PC3-xenograph tumor models (by 47% and 80% at 1 and 5 mg/kg, respectively.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number781661-94-7
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesNakamura, N., et al. 2012. Mol. Cell. Proteomics. 11, M111.0132434.
Tolcher, A.W., et al. 2008, J. Clin. Oncol. 26, 5198.
Nakahara, T., et al. 2007, Cancer Res. 67, 8014.