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508512 SNX-482 - CAS 203460-30-4 - Calbiochem

508512
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Tabulka spec. kláve

CAS #Empirical Formula
203460-30-4C₁₉₂H₂₇₄N₅₂O₆₀S₇

Products

Katalogové čísloBalení ks/bal.
5.08512.0001 Skleněná láhev 10 μg
Description
OverviewA peptidyl toxin present in the venom of African tarantula, Hysterocrates gigas that acts as a high affinity, reversible blocker of Cav2.3 (α1E, R-type) channels (IC50 = 15-30 nM). The inhibition appears to be voltage-dependent. At lower concentrations it is also shown to block native R-type Ca2+ current in rat neurohypophyseal nerve terminals, however, these effects are not observed at higher concentrations. Does not affect Na+ or K+ currents in several cultured cell types (~ 500 nM).
Catalogue Number508512
Brand Family Calbiochem®
References
ReferencesAbitbol, K. et al. 2012. J. Physiol. 590, 2977.
Newcomb, R., et al., 1998. Biochemistry. 37, 15353.
Product Information
CAS number203460-30-4
FormWhite solid
Hill FormulaC₁₉₂H₂₇₄N₅₂O₆₀S₇
Chemical formulaC₁₉₂H₂₇₄N₅₂O₆₀S₇
Quality LevelMQ100
Biological Information
Primary TargetCav2.3 channels
Primary Target IC<sub>50</sub>15-30 nM
Purity≥98% by HPLC
Physicochemical Information
Peptide SequenceGVDKAGCRYMFGGCSVNDDCCPRLGCHSLF→SYCAWDLTFSD (difulfid bond: 7-21, 14-26, 20-33)
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C.
Global Trade Item Number
Katalogové číslo GTIN
5.08512.0001 04055977262049