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559399 SB 203580, Sulfone - CAS 152121-46-5 - Calbiochem

SB 203580, Sulfone - CAS 152121-46-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl)-1H-imidazole, p38 MAP Kinase Inhibitor XII

Primary Target: P38K
559399
  
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Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
152121-46-5C₂₁H₁₆FN₃O₂S
Description
Overview

This product has been discontinued.



A cell permeable, reversible, and ATP-competitive sulfone analog of the p38 MAP kinase inhibitor SB 203580 (Cat. No. 559389). Potently inhibits p38 kinase (IC50 = 30 nM) and inhibits IL-1 production in human monocytes (IC50 = 200 nM).
Catalogue Number559399
Brand Family Calbiochem®
Synonyms4-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl)-1H-imidazole, p38 MAP Kinase Inhibitor XII
References
ReferencesGallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
Product Information
CAS number152121-46-5
ATP CompetitiveY
FormPale yellow solid
Hill FormulaC₂₁H₁₆FN₃O₂S
Chemical formulaC₂₁H₁₆FN₃O₂S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetP38K
Primary Target IC<sub>50</sub>30 nM and 200 nM against p38 kinase and IL-1 production, respectively, in human monocytes.
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
559399 0

Documentation

SB 203580, Sulfone - CAS 152121-46-5 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

SB 203580, Sulfone - CAS 152121-46-5 - Calbiochem Certificates of Analysis

TitleLot Number
559399

References

Přehled odkazů
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-January-2010 RFH
Synonyms4-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl)-1H-imidazole, p38 MAP Kinase Inhibitor XII
DescriptionA cell permeable, reversible, and ATP-competitive sulfone metabolite of the p38 MAP kinase inhibitor, SB 203580 (Cat. No. 559389). Potently inhibits p38 MAP kinase (IC50 = 30 nM). Also inhibits IL-1 production in human monocytes (IC50 = 200 nM).
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number152121-46-5
Chemical formulaC₂₁H₁₆FN₃O₂S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (200 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
Toxicity Standard Handling
ReferencesGallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.