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466220 S-Methylisothiourea, Sulfate

A highly selective, cell-permeable inhibitor of inducible nitric oxide synthase (iNOS).

S-Methylisothiourea, Sulfate MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Methyl-2-thiopseudourea, Sulfate, SMT

Primary Target: iNOS
466220
  
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Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
867-44-7(C₂H₆N₂S)₂ · H₂SO₄
Description
Overview

This product has been discontinued.




A highly selective, cell-permeable inhibitor of inducible nitric oxide synthase (iNOS). Reported to be 10 to 30-fold more potent than L-NMMA (Cat. No. 475886) as an inhibitor of iNOS in immunostimulated cultured macrophages (EC50 = 6 µM) and vascular smooth muscle cells (EC50 = 2 µM).
Catalogue Number466220
Brand Family Calbiochem®
Synonyms2-Methyl-2-thiopseudourea, Sulfate, SMT
References
ReferencesSouthan, G.J., et al. 1995. Br. J. Pharmacol. 114, 510.
Szabó, C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 12472.
Product Information
CAS number867-44-7
ATP CompetitiveN
FormWhite crystals
Hill Formula(C₂H₆N₂S)₂ · H₂SO₄
Chemical formula(C₂H₆N₂S)₂ · H₂SO₄
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetiNOS
Primary Target IC<sub>50</sub>EC50 = 6 µM against iNOS in immunostimulated cultured macrophages; EC50 = 2 µM against iNOS in vascular smooth muscle cells
Purity≥99% by elemental analysis
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSUM9200000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +15°C to +30°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
466220 0

Documentation

S-Methylisothiourea, Sulfate MSDS

Title

Safety Data Sheet (SDS) 

S-Methylisothiourea, Sulfate Certificates of Analysis

TitleLot Number
466220

References

Přehled odkazů
Southan, G.J., et al. 1995. Br. J. Pharmacol. 114, 510.
Szabó, C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 12472.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-August-2008 RFH
Synonyms2-Methyl-2-thiopseudourea, Sulfate, SMT
DescriptionA cell-permeable, highly selective inhibitor of inducible nitric oxide synthase (iNOS). Reported to be 10-30 fold more potent than L-NMMA (Cat. No. 475886) as an inhibitor of iNOS in immunostimulated cultured macrophages (EC50 = 6 µM) and vascular smooth muscle cells (EC50 = 2 µM).
FormWhite crystals
CAS number867-44-7
RTECSUM9200000
Chemical formula(C₂H₆N₂S)₂ · H₂SO₄
Structure formulaStructure formula
Purity≥99% by elemental analysis
SolubilityH₂O
Storage +15°C to +30°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsUnstable in solution; reconstitute just prior to use.
Toxicity Standard Handling
ReferencesSouthan, G.J., et al. 1995. Br. J. Pharmacol. 114, 510.
Szabó, C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 12472.