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533928 REV-ERB Agonist, SR10067 - CAS 1380548-02-6 - Calbiochem

A cell-permeable, selective, brain permeant, potent, high-affinity agonist of REV-ERB (IC₅₀ = 170 and 160 nM for REV-ERB alpha and beta, respectively

REV-ERB Agonist, SR10067 - CAS 1380548-02-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (3-((4-(Tert-butoxy)phenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)(naphthalen-1-yl)methanone

Primary Target: REV-ERB
533928
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Přehled

Tabulka spec. kláve

CAS #Empirical Formula
1380548-02-6C₃₁H₃₁NO₃

Products

Katalogové čísloBalení ks/bal.
5.33928.0001 Skleněná láhev 10 mg
Přidat k oblíbeným položkám
Description
OverviewA cell-permeable, bioavailable, tetrahydroisoquinolin amide that acts as a selective, potent, and high-affinity agonist of REV-ERB (IC50 = 170 nM for REV-ERBα and IC50 = 160 nM for REV-ERBβ in a REV-ERB ligand-binding domain co-transfection assay). Able to cross the blood brain barrier and remain above the IC50 value even after 6 h (30 mg/kg, i.p.). Displays minimal activities against a wide of other receptors, ion channels, and transporters when screened at 20 µM. Shown to induce wakefulness and suppress circadian wheel-running activity (ED50 = 20 mg/kg injected at Zeitgeiber time 6 (ZT6)) in mice. Reduces slow-wave sleep (SWS) and REM sleep when injected at ZT6 with decreased duration and reduces the number of episodes and duration of REM sleep. Also shown to reduce anxiety-like behavior in the marble-burying assay.
Catalogue Number533928
Brand Family Calbiochem®
Synonyms(3-((4-(Tert-butoxy)phenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)(naphthalen-1-yl)methanone
DescriptionREV-ERB Agonist, SR10067
References
ReferencesBanerjee, S., et al. 2014. Nat. Comm. 5, 5759.
Product Information
CAS number1380548-02-6
FormWhite solid
Hill FormulaC₃₁H₃₁NO₃
Chemical formulaC₃₁H₃₁NO₃
ReversibleY
Quality LevelMQ100
Biological Information
Primary TargetREV-ERB
Primary Target IC<sub>50</sub>170 nM for REV-ERB&alpha
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
5.33928.0001 04055977281613