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526610 PlGF-1, Human, Recombinant, S. frugiperda

PlGF-1, Human, Recombinant, S. frugiperda MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Placenta Growth Factor-1

526610
  
Purchase on Sigma-Aldrich

Přehled

Replacement Information

Tabulka spec. kláve

Purity
≥90% by SDS-PAGE
Description
Overview

This product has been discontinued.





Recombinant, human PlGF-1 (a 131 amino acid splice variant of PlGF) expressed in S. frugiperda insect cells. A dimeric glycoprotein with a high degree of sequence homology to vascular endothelial growth factor (VEGF). Has been shown to antagonize VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PIGF-1/VEGF heterodimers. Forms a homodimer with some degree of heterogeneity due to differential glycosylation. Has also been shown to form a biologically active heterodimer with VEGF. Binds immobilized rh-sFlt-1 (100 ng/ml) in the range of 0.1-10 ng/ml.
Catalogue Number526610
Brand Family Calbiochem®
SynonymsPlacenta Growth Factor-1
References
ReferencesEriksson, A., et al. 2002. Cancer Cell 1, 99.
Khaliq, A., et al. 1999. Lab. Invest. 79, 151.
Ziche, M., et al. 1997. Lab Invest. 76, 517.
Birkenhager, R., et al. 1996. Biochem. J. 316, 703.
Sawano, A., et al. 1996. Cell. Growth Differ. 7, 213.
Park, J.E., et al. 1994. J. Biol. Chem. 269, 25646.
Product Information
FormLyophilized
FormulationLyophilized from 50 mM acetic acid, BSA.
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by SDS-PAGE
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
526610 0

Documentation

PlGF-1, Human, Recombinant, S. frugiperda MSDS

Title

Safety Data Sheet (SDS) 

PlGF-1, Human, Recombinant, S. frugiperda Certificates of Analysis

TitleLot Number
526610

References

Přehled odkazů
Eriksson, A., et al. 2002. Cancer Cell 1, 99.
Khaliq, A., et al. 1999. Lab. Invest. 79, 151.
Ziche, M., et al. 1997. Lab Invest. 76, 517.
Birkenhager, R., et al. 1996. Biochem. J. 316, 703.
Sawano, A., et al. 1996. Cell. Growth Differ. 7, 213.
Park, J.E., et al. 1994. J. Biol. Chem. 269, 25646.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-June-2010 JSW
SynonymsPlacenta Growth Factor-1
DescriptionRecombinant, human PlGF-1 (a 131 amino acid splice variant of PlGF) expressed in S. frugiperda insect cells. Acts only as a weak mitogen for some endothelial cell types, but functions as a potent chemotactic agent for monocytes. Has been reported to be angiogenic in the CAM and rabbit cornea assays. Forms a homodimer with some degree of heterogeneity due to differential glycosylation. Has also been shown to form a biologically active heterodimer with VEGF. FLT-1 (VEGFR1) has been shown to be a high-affinity receptor for PIGF in several primary cell types; however, PIGF does not bind to KDR/flk-1 (VEGFR2). Binds immobilized rh-sFlt-1 (100 ng/ml) in the range of 0.1-10 ng/ml.
FormLyophilized
FormulationLyophilized from 50 mM acetic acid, BSA.
Purity≥90% by SDS-PAGE
SolubilityReconstitute in PBS or 100 mM acetic acid to a concentration ≥100 ng/µl.
Storage Avoid freeze/thaw
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
Toxicity Standard Handling
ReferencesEriksson, A., et al. 2002. Cancer Cell 1, 99.
Khaliq, A., et al. 1999. Lab. Invest. 79, 151.
Ziche, M., et al. 1997. Lab Invest. 76, 517.
Birkenhager, R., et al. 1996. Biochem. J. 316, 703.
Sawano, A., et al. 1996. Cell. Growth Differ. 7, 213.
Park, J.E., et al. 1994. J. Biol. Chem. 269, 25646.