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530618 Pin1 Inhibitor, DTM - CAS 725-32-6 - Calbiochem

530618
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Tabulka spec. kláve

CAS #Empirical Formula
725-32-6C₁₂H₂₀N₂S₃

Products

Katalogové čísloBalení ks/bal.
5.30618.0001 Skleněná láhev 10 mg
Description
OverviewA cell permeable thiuram monosulfide based compound that acts as a competitive inhibitor of Pin1 (EC50 = 4.1 µM, Ki = 50 nM). Binds to the active site of the PPIase domain of Pin1 hydrophobically and blocks the active pocket. Shown to specifically inhibit peptidyl-prolyl cis/trans isomerase activity in HeLa cells. Inhibits the proliferation of HCT116 cells (EC50 = 10 µM) by arresting cell cycle at the G0 phase. Also shown to reduce the endogenous Runx2 protein levels in the MC3T3-E1 cells. Displays excellent solubility in DMSO (~100 mM).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number530618
Brand Family Calbiochem®
SynonymsPPIase-Parvulin Inhibitor II
References
ReferencesYoon, W-J., et al. 2013. J. Cell Physiol. 228, 2377.
Tatara, Y., et al. 2009.Biochem Biophys Res Commun. 384, 394.
Product Information
CAS number725-32-6
FormYellow powder
Hill FormulaC₁₂H₂₀N₂S₃
Chemical formulaC₁₂H₂₀N₂S₃
ReversibleY
Quality LevelMQ100
Biological Information
Primary TargetPin1
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
5.30618.0001 04055977260984