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516354 Pentoxifylline

A non-selective phosphodiesterase inhibitor.

Pentoxifylline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione, PTX

Primary Target: endo toxin-induced synthesis of TNF-α
516354
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
6493-05-6C₁₃H₁₈N₄O₃
Description
Overview

This product has been discontinued.





A non-selective phosphodiesterase inhibitor. Inhibits endotoxin-induced synthesis of tumor necrosis factor-α (TNF-α). PTX inhibits the adhesion of T cells to the β1 and β2 integrin ligands VCAM-1 and ICAM-1. Also prevents the down-regulation of microsomal cytochrome P450 caused by lipopolysaccharides.
Catalogue Number516354
Brand Family Calbiochem®
Synonyms3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione, PTX
References
ReferencesGonzalez-Amaro, R., et al. 1998. J. Immunol. 161, 65.
Monshouwer, M., et al. 1996. Biochem. Pharmacol. 52, 1195.
Rosenthal, L.A., et al. 1992. J. Interferon. Res. 12, 403.
Zabel, P., et al. 1992. Immun. Infekt. 20, 80.
Thiel, M., et al. 1991. Biochem. Res. Biophys. Commun. 180, 53.
Product Information
CAS number6493-05-6
ATP CompetitiveN
FormWhite crystalline solid
Hill FormulaC₁₃H₁₈N₄O₃
Chemical formulaC₁₃H₁₈N₄O₃
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targetendo toxin-induced synthesis of TNF-α
Purity≥99% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSXH2475000
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
516354 0

Documentation

Pentoxifylline MSDS

Title

Safety Data Sheet (SDS) 

Pentoxifylline Certificates of Analysis

TitleLot Number
516354

References

Přehled odkazů
Gonzalez-Amaro, R., et al. 1998. J. Immunol. 161, 65.
Monshouwer, M., et al. 1996. Biochem. Pharmacol. 52, 1195.
Rosenthal, L.A., et al. 1992. J. Interferon. Res. 12, 403.
Zabel, P., et al. 1992. Immun. Infekt. 20, 80.
Thiel, M., et al. 1991. Biochem. Res. Biophys. Commun. 180, 53.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-October-2009 RFH
Synonyms3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione, PTX
DescriptionA non-selective phosphodiesterase inhibitor. Inhibits endotoxin-induced synthesis of tumor necrosis factor-α (TNF-α). PTX inhibits the adhesion of T cells to the β1 and β2 integrin ligands VCAM-1 and ICAM-1. Also prevents the down-regulation of microsomal P450 caused by lipopolysaccharides.
FormWhite crystalline solid
CAS number6493-05-6
RTECSXH2475000
Chemical formulaC₁₃H₁₈N₄O₃
Structure formulaStructure formula
Purity≥99% by TLC
SolubilityH₂O (50 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
Merck USA index14, 7136
ReferencesGonzalez-Amaro, R., et al. 1998. J. Immunol. 161, 65.
Monshouwer, M., et al. 1996. Biochem. Pharmacol. 52, 1195.
Rosenthal, L.A., et al. 1992. J. Interferon. Res. 12, 403.
Zabel, P., et al. 1992. Immun. Infekt. 20, 80.
Thiel, M., et al. 1991. Biochem. Res. Biophys. Commun. 180, 53.