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529531 PICK1 PDZ Domain Inhibitor, FSC231 - Calbiochem

The PICK1 PDZ Domain Inhibitor, FSC231 controls the biological activity of PICK1. This small molecule/inhibitor is primarily used for Neuroscience applications.

PICK1 PDZ Domain Inhibitor, FSC231 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E)-Ethyl-2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate

529531
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Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₁₃H₁₀Cl₂N₂O₃

Products

Katalogové čísloBalení ks/bal.
529531-10MG Skleněná láhev 10 mg
Description
OverviewA cell-permeable acryloylcarbamate compound that selectively targets the PDZ (PSD-95/Discs-large/ZO-1 homology) domain of PICK1 (protein interacting with C kinase 1), but not those of PSD-95 (postsynaptic density protein 95) and GRIP1 (glutamate receptor interacting protein 1), effectively competing against dopamine transporter/DAT (Ki ~10 µM), GluR2 (Ki ~10 µM), and mRluR7a, c-terminus binding to PICK1 PDZ. Shown to accelerate internalized GluR2 surface recycling and suppress both long-term depression and potentiation in rat and murine hippocampal neurons.
Catalogue Number529531
Brand Family Calbiochem®
Synonyms(E)-Ethyl-2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate
References
ReferencesThorsen, T.S., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 413.
Product Information
FormOff-white solid
Hill FormulaC₁₃H₁₀Cl₂N₂O₃
Chemical formulaC₁₃H₁₀Cl₂N₂O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconsitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
529531-10MG 04055977269697

Documentation

PICK1 PDZ Domain Inhibitor, FSC231 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

PICK1 PDZ Domain Inhibitor, FSC231 - Calbiochem Certificates of Analysis

TitleLot Number
529531

References

Přehled odkazů
Thorsen, T.S., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 413.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-March-2012 JSW
Synonyms(E)-Ethyl-2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate
DescriptionA cell-permeable acryloylcarbamate compound that selectively targets the PDZ (PSD-95/Discs-large/ZO-1 homology) domain of PICK1 (protein interacting with C kinase 1), but not PDZ domains of PSD-95 (postsynaptic density protein 95) and GRIP1 (glutamate receptor interacting protein 1), effectively competing against dopamine transporter/DAT (Ki ~10 µM in competitive binding assays), GluR2 (Ki ~10 µM in competitive binding assays), and mRluR7a (~70% inhibition by Co-IP using lysates from 50 µM FSC231-treated HEK293), c-terminus binding to PICK1 PDZ. Shown to accelerate GluR2 surface recycling after NMDR-induced internalization (t1/2 = 7.5 vs 10 min with and without 50 µM FSC231 treatment) in rat hippocampal neurons and prevent both LTD (% long-term depression = 74 vs 50 with and without 50 µM FSC231 treatment) and LTP (% long-term potentiation = 137 vs 266 with and without 50 µM FSC231 treatment) in murine hippocampal slices.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₃H₁₀Cl₂N₂O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconsitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Regulatory Review
ReferencesThorsen, T.S., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 413.