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506274 PACOCF₃ - CAS 141022-99-3 - Calbiochem

A novel Ca2+-independent and reversible inhibitor of phospholipase A₂ (PLA₂; IC₅₀ = 3.8 µM).

PACOCF₃ - CAS 141022-99-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Palmitoyl Trifluoromethyl Ketone

506274
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
141022-99-3C₁₇H₃₁F₃O

Products

Katalogové čísloBalení ks/bal.
506274-5MG Plastová ampulka 5 mg
Description
OverviewA novel Ca2+-independent and reversible inhibitor of phospholipase A2 (PLA2; IC50 = 3.8 µM). May also inhibit Ca2+-dependent PLA2 at much higher concentrations (IC50 = 45 µM).
Catalogue Number506274
Brand Family Calbiochem®
SynonymsPalmitoyl Trifluoromethyl Ketone
References
ReferencesConde-Frieboes, K., et al. 1996. J. Am. Chem. Soc. 118, 5519.
Lio, Y.C., et al. 1996. Biochim. Biophys. Acta 1302, 55.
Ackermann, E.J., et al. 1995. J. Biol. Chem. 270, 445.
Product Information
CAS number141022-99-3
ATP CompetitiveN
FormLiquid
FormulationIn ethanol.
Hill FormulaC₁₇H₃₁F₃O
Chemical formulaC₁₇H₃₁F₃O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPLA₂
Primary Target IC<sub>50</sub>3.8 µM and 45 µM against phospholipase A2 (PLA2) and Ca2+-dependent PLA2, respectively.
Purity≥97% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Product has a very low melting point. The product will change from a solid to a liquid if held in your hand or kept at room temperature or warmer for any period of time. It is best to keep the product cool while in use by placing it in the refrigerator or on ice during experimentation. Once diluted in buffer, do not store in aqueous solutions for >1 day.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
506274-5MG 04055977272437

Documentation

PACOCF₃ - CAS 141022-99-3 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

PACOCF₃ - CAS 141022-99-3 - Calbiochem Certificates of Analysis

TitleLot Number
506274

References

Přehled odkazů
Conde-Frieboes, K., et al. 1996. J. Am. Chem. Soc. 118, 5519.
Lio, Y.C., et al. 1996. Biochim. Biophys. Acta 1302, 55.
Ackermann, E.J., et al. 1995. J. Biol. Chem. 270, 445.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-April-2011 RFH
SynonymsPalmitoyl Trifluoromethyl Ketone
DescriptionA novel Ca2+-independent phospholipase A2 inhibitor (IC50 = 3.8 µM). May also inhibit Ca2+-dependent phospholipase A2 at higher concentrations (IC50 = 45 µM)
FormLiquid
FormulationIn ethanol.
CAS number141022-99-3
Chemical formulaC₁₇H₃₁F₃O
Structure formulaStructure formula
Purity≥97% by TLC
SolubilitySupplied as a solution in ethanol. To change the solvent, evaporate the ethanol with a stream of nitrogen and immediately reconstitute with the solvent of choice. Soluble in DMSO (30 mg/ml). Only minimally soluble in aqueous buffers; do not use basic buffers; unstable at basic pH.
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Product has a very low melting point. The product will change from a solid to a liquid if held in your hand or kept at room temperature or warmer for any period of time. It is best to keep the product cool while in use by placing it in the refrigerator or on ice during experimentation. Once diluted in buffer, do not store in aqueous solutions for >1 day.
Toxicity Standard Handling
ReferencesConde-Frieboes, K., et al. 1996. J. Am. Chem. Soc. 118, 5519.
Lio, Y.C., et al. 1996. Biochim. Biophys. Acta 1302, 55.
Ackermann, E.J., et al. 1995. J. Biol. Chem. 270, 445.