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538002 Nurr1 Agonist, SA00025

An orally bioavailable, brain-penetrating, highly potent agonist of nuclear receptor related 1 (Nurr1; EC₅₀ = 2.5 nM in HEK293 cells transfected with full length human Nurr1).

Nurr1 Agonist, SA00025 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(3-(2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl)phenyl)propan-2-ol, Nuclear Receptor Related 1 Agonist, SA00025

538002
  
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Description
Overview

This product has been discontinued.



An orally bioavailable, brain-penetrating, imidazo[1,2-a]pyridine derivative that acts as a highly potent agonist of nuclear receptor related 1 (Nurr1; EC50 = 2.5 nM in HEK293 cells transfected with full length human Nurr1). Does not affect a panel of 40 other nuclear receptors, including RXR. Shown to modulate the transcription of dopaminergic target genes when administered orally in rats. Displays anti-inflammatory effects and offers neuroprotection in the 6-OHDA lesion model of Parkinson's disease (30 mg/kg for 7 days, p.o.).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Catalogue Number538002
Brand Family Calbiochem®
Synonyms2-(3-(2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl)phenyl)propan-2-ol, Nuclear Receptor Related 1 Agonist, SA00025
References
ReferencesSmith, G.A., et al. 2015. Plos One. 10, e0121072.
Product Information
FormOff-white or faint peach solid
Hill FormulaC₂₂H₁₉ClN₂O
Chemical formulaC₂₂H₁₉ClN₂O
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetNurr1
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
538002 0

Documentation

Nurr1 Agonist, SA00025 MSDS

Title

Safety Data Sheet (SDS) 

References

Přehled odkazů
Smith, G.A., et al. 2015. Plos One. 10, e0121072.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-September-2016 JSW
Synonyms2-(3-(2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl)phenyl)propan-2-ol, Nuclear Receptor Related 1 Agonist, SA00025
DescriptionAn orally bioavailable, brain-penetrating, imidazo[1,2-a]pyridine derivative that acts as a highly potent agonist of nuclear receptor related 1 (Nurr1; EC50 = 2.5 nM in HEK293 cells transfected with full length human Nurr1). Does not affect a panel of 40 other nuclear receptors, including RXR. Shown to modulate the transcription of dopaminergic target genes when administered orally in rats. Displays anti-inflammatory effects and offers neuroprotection in the 6-OHDA lesion model of Parkinson's disease (30 mg/kg for 7 days, p.o.).
FormOff-white or faint peach solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₂H₁₉ClN₂O
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSmith, G.A., et al. 2015. Plos One. 10, e0121072.