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487960 Nociceptin - CAS 170713-75-4 - Calbiochem

487960
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Tabulka spec. kláve

CAS #Empirical Formula
170713-75-4C₇₉H₁₂₉N₂₇O₂₂

Products

Katalogové čísloBalení ks/bal.
487960-1MG Plastová ampulka 1 mg
Description
OverviewEndogenous ligand for the opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1). Has no significant activity on the µ, δ, or κ opioid receptors; however, nanomolar concentrations of nociceptin inhibit forskolin-stimulated adenylyl cyclase activity in cells transfected with the G-protein coupled receptor LC132, which is similar in sequence to the opioid receptor. Also reported to cause hypertension and bradycardia in mice.
Catalogue Number487960
Brand Family Calbiochem®
SynonymsOrphanin FQ, OFQ, NC, FGGFTGARKSARKLANQ
References
ReferencesMadeddu, P., et al. 1999. Hypertension 33, 914.
Sandin, J., et al. 1999. NeuroReport 10, 71.
Meunier, J., et al. 1995. Nature 377, 532.
Reinscheid, R.K., et al. 1995. Science 270, 792.
Product Information
CAS number170713-75-4
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₇₉H₁₂₉N₂₇O₂₂
Chemical formulaC₇₉H₁₂₉N₂₇O₂₂
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Biological Information
Primary TargetOpioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1)
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
Global Trade Item Number
Katalogové číslo GTIN
487960-1MG 04055977200447