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349254 NS-398 - CAS 123653-11-2 - Calbiochem

349254
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Tabulka spec. kláve

CAS #Empirical Formula
123653-11-2C₁₃H₁₈N₂O₅S

Products

Katalogové čísloBalení ks/bal.
349254-5MG Plastová ampulka 5 mg
Description
OverviewA cell-permeable selective inhibitor of COX-2 in vitro. Inhibits sheep placental COX-2 (IC50 = 3.8 µM) while COX-1 activity is unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations from 0.3 to 5 mg/kg.
Catalogue Number349254
Brand Family Calbiochem®
SynonymsN-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide
References
ReferencesOuellet, M., and Percival, M.D. 1995. Biochem. J. 306, 247.
Futaki, N., et al. 1994. Prostaglandins 47, 55.
Arai, I., et al. 1993. Res. Comm. Chem. Pathol. Pharmacol. 81, 259.
Futaki, N., et al. 1993. Gen. Pharmacol. 24, 105.
Futaki, N., et al. 1993. J. Pharm. Pharmacol. 45, 753.
Product Information
CAS number123653-11-2
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₁₃H₁₈N₂O₅S
Chemical formulaC₁₃H₁₈N₂O₅S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetCOX-2
Primary Target IC<sub>50</sub>3.8 µM against COX-2
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Global Trade Item Number
Katalogové číslo GTIN
349254-5MG 04055977193213