533718 Sigma-AldrichNOD2 Signaling Inhibitor II, GSK717 - CAS 1595278-21-9 - Calbiochem
A cell-permeable diamide that selectively blocks MDP-stimulated cytokine release and downstream NF-κB and MAPK signaling pathways.
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Synonyms: N-(2-(1-(2-(2,3-Dihydro-1H-inden-5-ylamino)-2-oxoethyl)-1H-benzo[d]imidazol-2-yl)ethyl)-N-methylbenzamide, Nucleotide-binding Oligomerization Domain 2 Signaling Inhibitor II, MDP/NOD2-Mediated Signaling Inhibitor, GSK 717
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| Katalogové číslo | Balení | ks/bal. | |
|---|---|---|---|
| 5.33718.0001 | Skleněná láhev | 10 mg |
| Description | |
|---|---|
| Overview | A cell-permeable benzimidazole diamide compound that acts as a potent, selective, reversible and muramyl dipeptide (MDP)-induced NOD2 (MDP/nucleotide-binding oligomerization domain 2)-mediated signaling inhibitor (IC50 = 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells). Does not affect NOD1, TNFR1, or TLR-2-mediated responses. Also shown to diminish synergy between NOD2 and TLR2. Reduces MDP-stimulated IL-8, IL-6, IL-1β, and TNFα release in primary human monocytes (~5 µM), but does not affect Pam2CSK4-stimulated IL-8 release. Due to a lack of typical activation loop/hinge-binding motif it is unlikely to act as a kinase inhibitor. NOD1 Inhibitor, Nodinitib-1 (Cat. No. 488004) is also available. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. |
| Catalogue Number | 533718 |
| Brand Family | Calbiochem® |
| Synonyms | N-(2-(1-(2-(2,3-Dihydro-1H-inden-5-ylamino)-2-oxoethyl)-1H-benzo[d]imidazol-2-yl)ethyl)-N-methylbenzamide, Nucleotide-binding Oligomerization Domain 2 Signaling Inhibitor II, MDP/NOD2-Mediated Signaling Inhibitor, GSK 717 |
| Description | NOD2 Signaling Inhibitor II, GSK717 |
| References | |
|---|---|
| References | Rickard, D.J., et al. 2013. PLoS ONE.D40 8, e69619. |
| Product Information | |
|---|---|
| CAS number | 1595278-21-9 |
| Form | White solid |
| Hill Formula | C₂₈H₂₈N₄O₂ |
| Chemical formula | C₂₈H₂₈N₄O₂ |
| Reversible | Y |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | NOD2 |
| Primary Target IC<sub>50</sub> | 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Katalogové číslo | GTIN |
| 5.33718.0001 | 04055977286663 |