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481414 NF-κB Activation Inhibitor VI, BOT-64 - CAS 113760-29-5 - Calbiochem

The NF-κB Activation Inhibitor VI, BOT-64, also referenced under CAS 113760-29-5, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

NF-κB Activation Inhibitor VI, BOT-64 - CAS 113760-29-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6,6-Dimethyl-2-(phenylimino)-6,7-dihydro-5H-benzo[1,3]oxathiol-4-one

481414
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
113760-29-5C₁₅H₁₅NO₂S
Description
OverviewA cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, presumably by targeting the Ser177 and/or Ser181 residues in the kinase's activation loop domain. Shown to inhibit LPS-induced NF-κB activation and nitrite production (IC50 = 1.0 & 0.7 µM, respectively) in RAW 264.7 cells in vitro and effectively prevent LPS-induced septic death in mice (70% survival rate with 30 mg/kg BOT-64, i.p.) in vivo.
Catalogue Number481414
Brand Family Calbiochem®
Synonyms6,6-Dimethyl-2-(phenylimino)-6,7-dihydro-5H-benzo[1,3]oxathiol-4-one
References
ReferencesKim, B.H., et al. 2008. Mol. Pharmacol. 73, 1309.
Product Information
CAS number113760-29-5
FormOff-white solid
Hill FormulaC₁₅H₁₅NO₂S
Chemical formulaC₁₅H₁₅NO₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
481414 0

Documentation

NF-κB Activation Inhibitor VI, BOT-64 - CAS 113760-29-5 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

NF-κB Activation Inhibitor VI, BOT-64 - CAS 113760-29-5 - Calbiochem Certificates of Analysis

TitleLot Number
481414

References

Přehled odkazů
Kim, B.H., et al. 2008. Mol. Pharmacol. 73, 1309.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms6,6-Dimethyl-2-(phenylimino)-6,7-dihydro-5H-benzo[1,3]oxathiol-4-one
DescriptionA cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, presumably by targeting the Ser177 and/or Ser181 residues in the kinase's activation loop domain. Shown to inhibit LPS-induced NF-κB activation and nitrite production (IC50 = 1.0 & 0.7 µM, respectively) in RAW 264.7 cells in vitro and effectively prevent LPS-induced septic death in mice (70% survival rate with 30 mg/kg BOT-64, i.p.) in vivo.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number113760-29-5
Chemical formulaC₁₅H₁₅NO₂S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml) or Ethanol (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesKim, B.H., et al. 2008. Mol. Pharmacol. 73, 1309.