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481408 NF-κB Activation Inhibitor II, JSH-23 - CAS 749886-87-1 - Calbiochem

NF-kB Activation Inhibitor II, JSH-23, CAS 749886-87-1, is a cell-permeable, selective inhibitor of nuclear translocation of NF-kB p65 and its transcription activity (IC50 = 7.1 µM).

NF-κB Activation Inhibitor II, JSH-23 - CAS 749886-87-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine

Primary Target: Blocks nuclear translocation of NF-κB p65 and its transcription activity
481408
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Tabulka spec. kláve

CAS #Empirical Formula
749886-87-1C₁₆H₂₀N₂

Products

Katalogové čísloBalení ks/bal.
481408-5MG Plastová ampulka 5 mg
Přidat k oblíbeným položkám
Description
OverviewA cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC50 = 7.1 µM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation.
Catalogue Number481408
Brand Family Calbiochem®
Synonyms4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine
References
ReferencesShin, H.M., et al. 2004. FEBS Lett. 571, 50.
Product Information
CAS number749886-87-1
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₁₆H₂₀N₂
Chemical formulaC₁₆H₂₀N₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationNF-kB Activation Inhibitor II, JSH-23, CAS 749886-87-1, is a cell-permeable, selective inhibitor of nuclear translocation of NF-kB p65 and its transcription activity (IC50 = 7.1 µM).
Biological Information
Primary TargetBlocks nuclear translocation of NF-κB p65 and its transcription activity
Primary Target IC<sub>50</sub>7.1 µM in a NF-κB reporter assay using RAW 264.7
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
481408-5MG 07790788050672