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480014 NDSB-221

NDSB-221 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(1-Methylpiperidinium)-1-propane Sulfonate

480014
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
160788-56-7C₉H₁₉NO₃S
Description
Overview

This product has been discontinued.





A non-detergent sulfobetaine useful for the renaturation of unfolded proteins. At 1.8 M, NDSB-221 yields about 35% in native hen egg white lysozyme (HEWL), which is about 10-fold higher than in the absence of NDSB-221. At about 1.5 M, NDSB-221 efficiently increases the renaturation of β-D-galactosidase.
Catalogue Number480014
Brand Family Calbiochem®
Synonyms3-(1-Methylpiperidinium)-1-propane Sulfonate
References
ReferencesGoldberg, M.E., et al. 1996. Folding & Design 1, 21.
Product Information
CAS number160788-56-7
FormWhite solid
Hill FormulaC₉H₁₉NO₃S
Chemical formulaC₉H₁₉NO₃S
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +15°C to +30°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
480014 0

Documentation

NDSB-221 Certificates of Analysis

TitleLot Number
480014

References

Přehled odkazů
Goldberg, M.E., et al. 1996. Folding & Design 1, 21.

Brochure

Title
Biological Detergents Brochure
Bulk Product Guide

Citations

Název
  • Marina V. Backer, et al. (2005) Vascular endothelial growth factor selectively targets boronated dendrimers to tumor vasculature. Molecular Cancer Therapeutics 4, 1423-1429.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision13-April-2011 RFH
    Synonyms3-(1-Methylpiperidinium)-1-propane Sulfonate
    DescriptionA member of the class of nondetergent sulfobetaines. Unlike CHAPS and other zwittergents, which are also sulfobetaines, NDSBs are nondenaturing even at 1 M concentrations. NDSBs have been used to improve the efficiency of solubilization of membrane proteins, to isolate nuclear proteins, to chromatographically purify halophilic proteins in low ionic strength buffers, and to crystallize proteins. They are zwitterionic over a wide pH range. They prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins. NDSBs can be easily removed by dialysis. NDSB-221 at 1.8 M yields about 35% in native hen egg white lysozyme (HEWL), which is about 10-fold higher than in the absence of NDSB-221. At about 1.5 M, NDSB-221 efficiently increases the renaturation of β-D-galactosidase.
    FormWhite solid
    CAS number160788-56-7
    Chemical formulaC₉H₁₉NO₃S
    Structure formulaStructure formula
    Purity≥95% by TLC
    SolubilityH₂O (100 mg/ml)
    Storage +15°C to +30°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Toxicity Irritant
    ReferencesGoldberg, M.E., et al. 1996. Folding & Design 1, 21.
    Citation
  • Marina V. Backer, et al. (2005) Vascular endothelial growth factor selectively targets boronated dendrimers to tumor vasculature. Molecular Cancer Therapeutics 4, 1423-1429.
    		•

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    Kategorie

    Life Science Research > Inhibitors and Biochemicals > Biochemicals > Detergents > Non-Detergent Sulfobetaines