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475867 Mn-cpx 3 - Calbiochem

Mn-cpx 3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
475867
  
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Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₃₀H₂₀Cl₂MnO₆
Description
Overview

This product has been discontinued.



A cell-permeable manganese complex of 7-hydroxyflavone that acts as a superoxide dismustase (SOD) mimetic and a neuroprotective agent against radical-induced damages. Shown to prevent the reduction of NBT by O2– • (IC50 = 1.18 µM) and exhibit ~10 times higher potency than Trolox (Cat. No. 648471) in inhibiting lipid peroxidation (IC50 = 6.15 µM) in vitro. Suppresses MAP (methamphetamine)-induced brain hypermotility in mice and shows protective effects against learning and memory impairment in a murine ischemic model in vivo.
Catalogue Number475867
Brand Family Calbiochem®
References
ReferencesVajragupta, O., et al. 2003. Bioorg. Med. Chem. 11, 2329.
Product Information
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₃₀H₂₀Cl₂MnO₆
Chemical formulaC₃₀H₂₀Cl₂MnO₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetSuperoxide dismustase (SOD) mimetic
Primary Target IC<sub>50</sub>1.18 µM in preventing the reduction of NBT by O2- • in vitro
Purity≥98% by elemental analysis
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
475867 0

Documentation

Mn-cpx 3 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Mn-cpx 3 - Calbiochem Certificates of Analysis

TitleLot Number
475867

References

Přehled odkazů
Vajragupta, O., et al. 2003. Bioorg. Med. Chem. 11, 2329.

Brochure

Title
Pathways and Biomarkers of Oxidative Stress
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-October-2007 RFH
DescriptionA cell-permeable manganese complex of 7-hydroxyflavone that acts as a superoxide dismutase (SOD) mimetic and exhibits neuroprotective effects against radical-induced damage. Shown to prevent the reduction of NBT by O2− • (IC50 = 1.18 µM). Reported to exhibit ~10 times higher potency than Trolox (Cat. No. 648471) in inhibiting lipid peroxidation (IC50 = 6.15 µM) in vitro. Suppresses MAP (methamphetamine)-induced brain hypermotility in mice and shows protective effects against learning and memory impairment in a murine ischemic model.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₀H₂₀Cl₂MnO₆
Structure formulaStructure formula
Purity≥98% by elemental analysis
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesVajragupta, O., et al. 2003. Bioorg. Med. Chem. 11, 2329.