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654271 MetAP2 Inhibitor, A832234 - Calbiochem

654271
  
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Tabulka spec. kláve

Empirical Formula
C₂₄H₂₉FN₂O₄S
Description
Overview

This product has been discontinued.



A cell-permeable anthranilic acid sulfonamide compound that acts as a potent and reversible inhibitor of methionine aminopetidase-2 (MetAP2, IC50 = 11 nM). Acts by directly targeting the active site of MetAP2 without any significant binding to human serum albumin. Also shown to inhibit cellular MetAP2 activity (EC50 = 5.3 nM) and block the proliferation of HT1080 fibrosarcoma cells (EC50 = 6 nM).

Catalogue Number654271
Brand Family Calbiochem®
SynonymsMethionine aminopeptidase-2 Inhibitor, 2-[({2-[(1Z)-3-(Diethylamino)-1-propenyl]-4-fluorophenyl}-sulfonyl)amino]-5,6,7,8-tetrahydro-1-naphthalenecarboxylic Acid, Methionyl aminopeptidase 2 Inhibitor
References
ReferencesSheppard, G. S., et al. 2006. J Med Chem. 49, 3832
Product Information
FormLight beige solid
Hill FormulaC₂₄H₂₉FN₂O₄S
ReversibleY
Structure formula ImageStructure formula Image
Biological Information
Primary TargetMetAP2
Primary Target IC<sub>50</sub>11 nM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
654271 0