Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

428206 Lck Inhibitor II - CAS 918870-43-6 - Calbiochem

Lck Inhibitor II - CAS 918870-43-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(2-(1H-Benzo[d]imidazol-1-yl)-6-(2-morpholinoethoxy)pyrimidin-4-ylamino)-4-methylphenol

428206
  
Purchase on Sigma-Aldrich

Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
918870-43-6C₂₄H₂₆N₆O₃
Description
Overview

This product has been discontinued.



A cell-permeable, ATP binding site-targeting, tri-substituted pyrimidine that acts as a highly potent Lck (lymphocyte specific kinase) inhibitor (IC50 = 3 nM; [ATP] = 10 µM). Shown to block IL-2 release in Jurkat E6-1 T cell line (IC50 = 54 nM) stimulated by CD3 cross-linking and PMA.
Catalogue Number428206
Brand Family Calbiochem®
Synonyms3-(2-(1H-Benzo[d]imidazol-1-yl)-6-(2-morpholinoethoxy)pyrimidin-4-ylamino)-4-methylphenol
References
ReferencesSabat, M., et al. 2006. Bioorg. Med. Chem. Lett. 16, 5973.
Product Information
CAS number918870-43-6
FormLight yellow solid
Hill FormulaC₂₄H₂₆N₆O₃
Chemical formulaC₂₄H₂₆N₆O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25

Do not breathe dust.
Avoid contact with skin and eyes.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
428206 0

Documentation

Lck Inhibitor II - CAS 918870-43-6 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Lck Inhibitor II - CAS 918870-43-6 - Calbiochem Certificates of Analysis

TitleLot Number
428206

References

Přehled odkazů
Sabat, M., et al. 2006. Bioorg. Med. Chem. Lett. 16, 5973.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms3-(2-(1H-Benzo[d]imidazol-1-yl)-6-(2-morpholinoethoxy)pyrimidin-4-ylamino)-4-methylphenol
DescriptionA cell-permeable, ATP binding site-targeting, tri-substituted pyrimidine that acts as a highly potent Lck (lymphocyte specific kinase) inhibitor (IC50 = 3 nM; [ATP] = 10 µM). Shown to block IL-2 release in Jurkat E6-1 T cell line (IC50 = 54 nM) stimulated by CD3 cross-linking and PMA.
FormLight yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number918870-43-6
Chemical formulaC₂₄H₂₆N₆O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (35 mg/ml) or Ethanol (20 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesSabat, M., et al. 2006. Bioorg. Med. Chem. Lett. 16, 5973.