Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

440208 LY 231617

A potent antioxidant that readily crosses the blood-brain barrier.

LY 231617 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2,6-bis(1,1-Dimethylethyl)-4-[[(1-ethyl)amino]methyl]phenol, HCl

440208
  
Purchase on Sigma-Aldrich

Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
141545-89-3C₁₇H₂₉NO · HCl
Description
Overview

This product has been discontinued.





A potent antioxidant that readily crosses the blood-brain barrier. Significantly reduces ischemia-induced or hydrogen peroxide-induced neuronal damage and inhibits lipid peroxidation (IC50 = 22 µM). Prevents nuclear translocation of activated NF-κB in hippocampal neurons.
Catalogue Number440208
Brand Family Calbiochem®
Synonyms2,6-bis(1,1-Dimethylethyl)-4-[[(1-ethyl)amino]methyl]phenol, HCl
References
ReferencesToung, T.J., et al. 2000. Crit. Care Med. 28, 196.
Fuson, K.S., et al. 1999. J. Neurochem. 72, 1154.
Clemens, J.A., et al. 1998. Stroke 29, 677.
Callaway, J.K., et al. 1998. J. Pharmacol. Toxicol. Methods 39, 155.
O’Neill, M.J., et al. 1997. Brain Res. 760, 170.
Clemens, J.A., et al. 1993. Stroke 24, 716.
Product Information
CAS number141545-89-3
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₇H₂₉NO · HCl
Chemical formulaC₁₇H₂₉NO · HCl
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targetinhibits lipid peroxidation
Primary Target IC<sub>50</sub>22 µM against lipid peroxidation
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
440208 0

Documentation

LY 231617 MSDS

Title

Safety Data Sheet (SDS) 

LY 231617 Certificates of Analysis

TitleLot Number
440208

References

Přehled odkazů
Toung, T.J., et al. 2000. Crit. Care Med. 28, 196.
Fuson, K.S., et al. 1999. J. Neurochem. 72, 1154.
Clemens, J.A., et al. 1998. Stroke 29, 677.
Callaway, J.K., et al. 1998. J. Pharmacol. Toxicol. Methods 39, 155.
O’Neill, M.J., et al. 1997. Brain Res. 760, 170.
Clemens, J.A., et al. 1993. Stroke 24, 716.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2008 RFH
Synonyms2,6-bis(1,1-Dimethylethyl)-4-[[(1-ethyl)amino]methyl]phenol, HCl
DescriptionA potent antioxidant that readily crosses the blood-brain barrier. Significantly reduces ischemia-induced or hydrogen peroxide-induced neuronal damage. An inhibitor of lipid peroxidation (IC50 = 22 µM). Prevents nuclear translocation of activated NF-κB in hippocampal neurons.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number141545-89-3
Chemical formulaC₁₇H₂₉NO · HCl
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or Methanol (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesToung, T.J., et al. 2000. Crit. Care Med. 28, 196.
Fuson, K.S., et al. 1999. J. Neurochem. 72, 1154.
Clemens, J.A., et al. 1998. Stroke 29, 677.
Callaway, J.K., et al. 1998. J. Pharmacol. Toxicol. Methods 39, 155.
O’Neill, M.J., et al. 1997. Brain Res. 760, 170.
Clemens, J.A., et al. 1993. Stroke 24, 716.