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420135 JNK Inhibitor VIII - CAS 894804-07-0 - Calbiochem

420135
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Katalogové čísloBalení ks/bal.
420135-5MG Plastová ampulka 5 mg
Description
OverviewA cell-permeable pyridinylamide compound that acts as an ATP-competitive, reversible inhibitor of JNK (Ki = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively) and displays excellent selectivity over 72 other kinases. Inhibits c-jun phosphorylation with an EC50 of 920 nM in HepG2 cells. Preferentially blocks the growth of PTEN null mouse embryonic fibroblasts.
Catalogue Number420135
Brand Family Calbiochem®
SynonymsN-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide
References
ReferencesVivanco, I., et al. 2007. Cancer Cell 11, 555.
Szczepankiewicz, B. G., et al. 2006. J. Med. Chem. 49, 3563.
Product Information
CAS number894804-07-0
ATP CompetitiveY
FormBrown solid
Hill FormulaC₁₈H₂₀N₄O₄
Chemical formulaC₁₈H₂₀N₄O₄
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationJNK Inhibitor VIII, CAS 894804-07-0, is a cell-permeable, ATP-competitive, reversible inhibitor of JNK (Ki = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively).
Biological Information
Primary TargetJNK
Primary Target K<sub>i</sub>2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
420135-5MG 04055977187656