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420101 JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem

420101
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
202475-60-3C₁₆H₁₅N₃O₃

Products

Katalogové čísloBalení ks/bal.
420101-5MG Plastová ampulka 5 mg
Description
OverviewA cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC50 = 78 µM). Has no effect on JAK1, JAK2, or Zap/Syk or Src tyrosine kinases. Acts as a potent inhibitor of glioblastoma cell adhesion and migration. Also reported to block thrombin-induced platelet aggregation.
Catalogue Number420101
Brand Family Calbiochem®
Synonyms4-(4ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, WHI-P131
References
ReferencesTibbles, H.E., et al. 2001. J. Biol. Chem. 276, 17815.
Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.
Product Information
CAS number202475-60-3
ATP CompetitiveY
FormWhite to off-white solid
Hill FormulaC₁₆H₁₅N₃O₃
Chemical formulaC₁₆H₁₅N₃O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetJanus family kinase 3
Primary Target IC<sub>50</sub>78 µM against Janus family kinase 3
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
420101-5MG 04055977187892

Documentation

JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem Certificates of Analysis

TitleLot Number
420101

References

Přehled odkazů
Tibbles, H.E., et al. 2001. J. Biol. Chem. 276, 17815.
Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.

Technical Info

Title
JAK/STAT Signaling Research Focus
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms4-(4ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, WHI-P131
DescriptionA cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3) (IC50 = 78 µM). Has no effect on either JAK1, JAK2, Zap/Syk or Src kinases. Blocks thrombin-induced platelet aggregation.
FormWhite to off-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number202475-60-3
Chemical formulaC₁₆H₁₅N₃O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTibbles, H.E., et al. 2001. J. Biol. Chem. 276, 17815.
Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.