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416157 Isohelenin, Inula sp. - Calbiochem

Isohelenin, Inula sp. - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Isoalantolactone

Primary Target: NF-κB activation
416157
  
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Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₁₅H₂₀O₂
Description
Overview

This product has been discontinued.



A cell-permeable sesquiterpene lactone with anti-inflammatory properties. Acts as a highly specific, potent, irreversible inhibitor of NF-κB activation that acts by preventing IκBα degradation. Does not affect the DNA binding activity of activated NF-κB, or inhibit p59fyn and Src kinase activities. Inhibits IL-8 gene expression in cultured human respiratory epithelium in vitro, and iNOS gene expression in cultured rat aortic smooth muscle cells. Offers protection against endotoxic shock in vivo.
Catalogue Number416157
Brand Family Calbiochem®
SynonymsIsoalantolactone
References
ReferencesSheehan, M., et al. 2002. J. Endotoxin. Res. 8, 99.
Mazor, R.L., et al. 2000. Cytokine 12, 239.
Wong. H.R., and Menendez, I.Y., 1999. Biochem. Biophys. Res. Commun. 262, 375.
Hehner, S.P., et al. 1998. J. Biol. Chem. 273, 1288.
Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₅H₂₀O₂
Chemical formulaC₁₅H₂₀O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNF-κB activation
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
416157 0

Documentation

Isohelenin, Inula sp. - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Isohelenin, Inula sp. - Calbiochem Certificates of Analysis

TitleLot Number
416157

References

Přehled odkazů
Sheehan, M., et al. 2002. J. Endotoxin. Res. 8, 99.
Mazor, R.L., et al. 2000. Cytokine 12, 239.
Wong. H.R., and Menendez, I.Y., 1999. Biochem. Biophys. Res. Commun. 262, 375.
Hehner, S.P., et al. 1998. J. Biol. Chem. 273, 1288.
Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-July-2008 RFH
SynonymsIsoalantolactone
DescriptionA cell-permeable sesquiterpene lactone with anti-inflammatory properties. Acts as a highly specific, potent, and irreversible inhibitor of NF-κB activation by preventing IκBα degradation. Does not affect the DNA binding activity of activated NF-κB or inhibit Fyn and Src kinase activities. Also reported to inhibit IL-8 gene expression in cultured human respiratory epithelium and iNOS gene expression in cultured rat aortic smooth muscle cells. Shown to protect against endotoxic shock in rats.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₅H₂₀O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or Ethanol (20 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesSheehan, M., et al. 2002. J. Endotoxin. Res. 8, 99.
Mazor, R.L., et al. 2000. Cytokine 12, 239.
Wong. H.R., and Menendez, I.Y., 1999. Biochem. Biophys. Res. Commun. 262, 375.
Hehner, S.P., et al. 1998. J. Biol. Chem. 273, 1288.
Bork, P.M., et al. 1997. FEBS Lett. 402, 85.