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566321 InSolution™ Sirtinol - Calbiochem

InSolution™ Sirtinol - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide, Sir Two Inhibitor Naphthol, SIRT1 Inhibitor I, SIRT1/2 Inhibitor I, SIRT2 Inhibitor III

Primary Target: ySir2
566321
Purchase on Sigma-Aldrich

Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₂₆H₂₂N₂O₂

Products

Katalogové čísloBalení ks/bal.
566321-1MG Plastová ampulka 1 mg
Description
Catalogue Number566321
Brand Family Calbiochem®
Synonyms2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide, Sir Two Inhibitor Naphthol, SIRT1 Inhibitor I, SIRT1/2 Inhibitor I, SIRT2 Inhibitor III
References
ReferencesMai, A., et al. 2005. J. Med. Chem. 48, 7789.
Grozinger, C.M., et al. 2001. J. Biol. Chem. 276, 38837.
Product Information
ATP CompetitiveN
FormLiquid
FormulationA 10 mM (1 mg/254 µl) solution of Sirtinol (Cat. No. 566320) in DMSO.
Hill FormulaC₂₆H₂₂N₂O₂
Chemical formulaC₂₆H₂₂N₂O₂
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetySir2
Primary Target IC<sub>50</sub>48 µM, 131 µM and 58 µM for ySir2, hSIRT1 and hSIRT2, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and refrigerate (4°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
566321-1MG 04055977191387

Documentation

InSolution™ Sirtinol - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

InSolution™ Sirtinol - Calbiochem Certificates of Analysis

TitleLot Number
566321

References

Přehled odkazů
Mai, A., et al. 2005. J. Med. Chem. 48, 7789.
Grozinger, C.M., et al. 2001. J. Biol. Chem. 276, 38837.

Data Sheet

Title
SIRTainty™ Class III HDAC Assay
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-October-2007 JSW
Synonyms2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide, Sir Two Inhibitor Naphthol, SIRT1 Inhibitor I, SIRT1/2 Inhibitor I, SIRT2 Inhibitor III
DescriptionA cell-permeable 2-hydroxy-1-napthaldehyde derivative that acts as a specific and a direct inhibitor of sirtuin class of histone deacetylase (HDAC) activity. Does not affect human HDAC1. Reported to block Sir2p transcriptional silencing activity in vivo (IC50 = 25 µM) and NAD-dependent HDAC activity in purified recombinant yeast Sir2p and human SIRT2 in vitro (IC50 = 68 µM and 38 µM, respectively).
FormLiquid
FormulationA 10 mM (1 mg/254 µl) solution of Sirtinol (Cat. No. 566320) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₆H₂₂N₂O₂
Structure formulaStructure formula
Purity≥97% by HPLC
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and refrigerate (4°C).
Toxicity Irritant
ReferencesMai, A., et al. 2005. J. Med. Chem. 48, 7789.
Grozinger, C.M., et al. 2001. J. Biol. Chem. 276, 38837.