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565787 InSolution™ γ-Secretase Inhibitor XIX

InSolution™ γ-Secretase Inhibitor XIX MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (2S,3R)-3-(3,4-Difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((3S)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-butyramide

565787
  
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Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₃₁H₂₄F₃N₃O₃
Description
Overview

This product has been discontinued.



Please refer to our complete listing of secretase inhibitors for possible alternatives.






A cell-permeable benzodiazepinyl-γ-hydroxybutyramide compound that acts as a highly potent γ-secretase inhibitor (IC50 = 60 pM towards Aβ40 secretion in SH-SY5Y cells overexpressing spβA4CTF).
Catalogue Number565787
Brand Family Calbiochem®
Synonyms(2S,3R)-3-(3,4-Difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((3S)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-butyramide
References
ReferencesChurcher, I., et al. 2003. J. Med. Chem. 46, 2275.
Product Information
FormLiquid
FormulationA 5 mM solution (100 µg/37 µl) in DMSO.
Hill FormulaC₃₁H₂₄F₃N₃O₃
Chemical formulaC₃₁H₂₄F₃N₃O₃
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
565787 0

Documentation

InSolution™ γ-Secretase Inhibitor XIX Certificates of Analysis

TitleLot Number
565787

References

Přehled odkazů
Churcher, I., et al. 2003. J. Med. Chem. 46, 2275.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-September-2008 RFH
Synonyms(2S,3R)-3-(3,4-Difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((3S)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-butyramide
DescriptionA cell-permeable, highly potent γ-secretase inhibitor. Reported to inhibit Aβ40 secretion in SH-SY5Y cells overexpressing spβA4CTF (IC50 = 60 pM).
FormLiquid
FormulationA 5 mM solution (100 µg/37 µl) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₁H₂₄F₃N₃O₃
Structure formulaStructure formula
Purity≥95% by HPLC
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesChurcher, I., et al. 2003. J. Med. Chem. 46, 2275.