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565794 InSolution™ β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem

565794
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Tabulka spec. kláve

CAS #Empirical Formula
797035-11-1C₃₁H₃₈N₄O₅S

Products

Katalogové čísloBalení ks/bal.
565794-500UG Skleněná láhev 500 μg
Description
OverviewA cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 0.23 µM, 7.6 µM and >50 µM for BACE-2, cathepsin D, and renin, respectively). The solid form of this compound (Cat. No. 565788) is also available.
Catalogue Number565794
Brand Family Calbiochem®
SynonymsN-(1S, 2R)-1-Benzyl-3-(cyclopropylamino)-2-hydroxypropyl)-5-(methyl(methylsulfonyl)amino-Nʹ-((1R)-1-phenylethyl)isophthalamide
References
ReferencesStachel, S.J., et al. 2004. J. Med. Chem. 47, 6447.
Product Information
CAS number797035-11-1
FormLiquid
FormulationA 10 mM (500 µg/86.4 µL) solution of β-Secretase Inhibitor IV (Cat. No. 565788) in DMSO.
Hill FormulaC₃₁H₃₈N₄O₅S
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary Targetβ-Secretase
Primary Target IC<sub>50</sub>15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. For short term storage, aliquots are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
565794-500UG 04055977191905