565794 Sigma-AldrichInSolution™ β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem
The InSolution™ β-Secretase Inhibitor, also referenced under CAS 797035-11-1, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applicat
More>> The InSolution™ β-Secretase Inhibitor, also referenced under CAS 797035-11-1, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications. Less<<InSolution™ β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: N-(1S, 2R)-1-Benzyl-3-(cyclopropylamino)-2-hydroxypropyl)-5-(methyl(methylsulfonyl)amino-Nʹ-((1R)-1-phenylethyl)isophthalamide
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Tabulka spec. kláve
| CAS # | Empirical Formula |
|---|---|
| 797035-11-1 | C₃₁H₃₈N₄O₅S |
Products
| Katalogové číslo | Balení | ks/bal. | |
|---|---|---|---|
| 565794-500UG | Skleněná láhev | 500 μg |
| Description | |
|---|---|
| Overview | A cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 0.23 µM, 7.6 µM and >50 µM for BACE-2, cathepsin D, and renin, respectively). The solid form of this compound (Cat. No. 565788) is also available. |
| Catalogue Number | 565794 |
| Brand Family | Calbiochem® |
| Synonyms | N-(1S, 2R)-1-Benzyl-3-(cyclopropylamino)-2-hydroxypropyl)-5-(methyl(methylsulfonyl)amino-Nʹ-((1R)-1-phenylethyl)isophthalamide |
| References | |
|---|---|
| References | Stachel, S.J., et al. 2004. J. Med. Chem. 47, 6447. |
| Product Information | |
|---|---|
| CAS number | 797035-11-1 |
| Form | Liquid |
| Formulation | A 10 mM (500 µg/86.4 µL) solution of β-Secretase Inhibitor IV (Cat. No. 565788) in DMSO. |
| Hill Formula | C₃₁H₃₈N₄O₅S |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | β-Secretase |
| Primary Target IC<sub>50</sub> | 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Katalogové číslo | GTIN |
| 565794-500UG | 04055977191905 |