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475821 InSolution™ Microcystin-LR, Microcystis aeruginosa - Calbiochem

InSolution™ Microcystin-LR, Microcystis aeruginosa - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A)
475821
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Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₄₉H₇₄N₁₀O₁₂

Products

Katalogové čísloBalení ks/bal.
475821-250UG Plastic Bag(s) 250 μg
Description
Catalogue Number475821
Brand Family Calbiochem®
References
ReferencesCraig, M., et al. 1996. Biochem. Cell Biol. 74, 569.
Nishiwaki, R., et al. 1994. Cancer Lett. 83, 283.
Amick, G.D., et al. 1992. Biochem. J. 287, 1019.
Davidson, H.W., et al. 1992. J. Cell Biol. 116, 1343.
Nishiwaki-Matsushima, R., et al. 1992. J. Cancer Res. Clin. Oncol. 118, 420.
Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
MacKintosh, C., et al. 1990. FEBS Lett. 264, 187.
Cohen, P., et al. 1989. FEBS Lett. 250, 596.
Carmichael, W.W. 1988. in Handbook of Natural Toxins 3, Marine Toxins and Venoms (Tu, A.T., Ed.) p. 121, Decker, New York.
Product Information
ATP CompetitiveN
DeclarationNot available for sale outside of the United States.
FormLiquid
FormulationA 2.5 mM (250 µg/100 µl) solution of Microcystin-LR, Microcystis aeruginosa (Cat. No. 475815) in DMSO.
Hill FormulaC₄₉H₇₄N₁₀O₁₂
Chemical formulaC₄₉H₇₄N₁₀O₁₂
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetprotein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A)
Primary Target IC<sub>50</sub>1.7 nM, 40 pM, against protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A), respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
End use certificateY
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
475821-250UG 04055977184853

Documentation

InSolution™ Microcystin-LR, Microcystis aeruginosa - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

InSolution™ Microcystin-LR, Microcystis aeruginosa - Calbiochem Certificates of Analysis

TitleLot Number
475821

References

Přehled odkazů
Craig, M., et al. 1996. Biochem. Cell Biol. 74, 569.
Nishiwaki, R., et al. 1994. Cancer Lett. 83, 283.
Amick, G.D., et al. 1992. Biochem. J. 287, 1019.
Davidson, H.W., et al. 1992. J. Cell Biol. 116, 1343.
Nishiwaki-Matsushima, R., et al. 1992. J. Cancer Res. Clin. Oncol. 118, 420.
Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
MacKintosh, C., et al. 1990. FEBS Lett. 264, 187.
Cohen, P., et al. 1989. FEBS Lett. 250, 596.
Carmichael, W.W. 1988. in Handbook of Natural Toxins 3, Marine Toxins and Venoms (Tu, A.T., Ed.) p. 121, Decker, New York.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-August-2008 RFH
DescriptionCyclic heptapeptide toxin isolated from the freshwater cyanobacteria, Microcystis aeruginosa. Potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Unlike Okadaic Acid (Cat. No. 495604), microcystin-LR is effective on both PP1 (IC50 = 1.7 nM) and PP2A (IC50 = 40 pM). Reacts with phosphatase in a two-step mechanism involving rapid binding and inactivation of the catalytic subunit followed by slower covalent interactions. Has no effect on protein kinases, making it useful for reducing contaminating phosphatase activities in protein kinase assays.
FormLiquid
FormulationA 2.5 mM (250 µg/100 µl) solution of Microcystin-LR, Microcystis aeruginosa (Cat. No. 475815) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₄₉H₇₄N₁₀O₁₂
Structure formulaStructure formula
Purity≥95% by HPLC
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Highly Toxic
ReferencesCraig, M., et al. 1996. Biochem. Cell Biol. 74, 569.
Nishiwaki, R., et al. 1994. Cancer Lett. 83, 283.
Amick, G.D., et al. 1992. Biochem. J. 287, 1019.
Davidson, H.W., et al. 1992. J. Cell Biol. 116, 1343.
Nishiwaki-Matsushima, R., et al. 1992. J. Cancer Res. Clin. Oncol. 118, 420.
Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
MacKintosh, C., et al. 1990. FEBS Lett. 264, 187.
Cohen, P., et al. 1989. FEBS Lett. 250, 596.
Carmichael, W.W. 1988. in Handbook of Natural Toxins 3, Marine Toxins and Venoms (Tu, A.T., Ed.) p. 121, Decker, New York.