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420326 IRTK Activator III, DDN - Calbiochem

The IRTK Activator III, DDN modulates the biological activity of IRTK. This small molecule/inhibitor is primarily used for Biochemicals applications.

IRTK Activator III, DDN - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5,8-Diacetyloxy-2,3-dichloro-1,4-naphthoquinone

420326
  
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Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₁₄H₈Cl₂O₆
Description
Overview

This product has been discontinued.



An orally bioavilable diacetyloxy-naphthoquinone compound that directly targets insulin receptor tyrosine kinase (IRTK) domain and specifically increases IR kinase activity with no effect on IGF-1R and EGFR. Shown to rapidly phosphorylate IR (Tyr1146 and Tyr1158/1162/1163) and IRS-1 and selectively activate insulin signaling Akt (Thr473) and ERK pathways in CHO-IGF-IR cells at 5 µM. Sensitizes insulin action, enhances glucose uptake in differentiated 3T3-L1 adipocytes and decreases blood glucose levels in both normal and diabetic C57BL/6J mice (20 mg/kg, p.o.).
Catalogue Number420326
Brand Family Calbiochem®
Synonyms5,8-Diacetyloxy-2,3-dichloro-1,4-naphthoquinone
References
ReferencesHe, K., et al. 2011. J. Biol. Chem. 286, 37379.
Product Information
FormPale yellow-green powder
Hill FormulaC₁₄H₈Cl₂O₆
Chemical formulaC₁₄H₈Cl₂O₆
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
420326 0

Documentation

IRTK Activator III, DDN - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

IRTK Activator III, DDN - Calbiochem Certificates of Analysis

TitleLot Number
420326

References

Přehled odkazů
He, K., et al. 2011. J. Biol. Chem. 286, 37379.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-August-2012 JSW
Synonyms5,8-Diacetyloxy-2,3-dichloro-1,4-naphthoquinone
DescriptionAn orally bioavilable diacetyloxy-naphthoquinone compound that directly targets insulin receptor tyrosine kinase (IRTK) domain and specifically increases IR kinase activity with no effect on IGF-1R and EGFR. Shown to rapidly phosphorylate IR (Tyr1146 and Tyr1158/1162/1163) and IRS-1 and selectively activate insulin signaling Akt (Thr473) and ERK pathways in CHO-IGF-IR cells at 5 µM. Sensitizes insulin action, enhances glucose uptake in differentiated 3T3-L1 adipocytes and decreases blood glucose levels in both normal and diabetic C57BL/6J mice (20 mg/kg, p.o.).
FormPale yellow-green powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₄H₈Cl₂O₆
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from moisture
Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesHe, K., et al. 2011. J. Biol. Chem. 286, 37379.