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382115 Histone Acetyl Transferase Inhibitor VII, CTK7A - Calbiochem

382115
Purchase on Sigma-Aldrich

Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₂₈H₂₃N₂NaO₆

Products

Katalogové čísloBalení ks/bal.
382115-10MG Skleněná láhev 10 mg
Description
OverviewA cell-permeable and water soluble hydrazinobenzoylcurcumin (HBC) compound that acts as a selective, reversible and mixed mode inhibitor of p300/CBP and PCAF histone acetyltransferases (IC50 ≤ 25 and 50 µM, respectively) with minimal activity towards other histone modifying enzymes like, G9a, CARM1, HDAC1, SIRT2 and TIP60 (IC50 > 100 µM). Blocks the autoacetylation of p300 and PCAF and histone acetylation, downregulates cyclin E expression and induces senescence-like growth arrest at 100 µM in KB cells. Further, suppresses tumor growth in xenograft oral tumor nude mouse model (100 mg/kg, i.p., b.i.d.) and reduces H3K14 and H3K9 acetylation levels. Reported to potently inhibit bFGF-induced bovine aortic endothelial cells (BAECs) invasion and tube formation with an IC50 of 0.93 µM and binds to Ca2+/calmodulin with high-affinity (Kd = 8.11 µM) and antagonize its functions in HCT15 cells.
Catalogue Number382115
Brand Family Calbiochem®
SynonymsSodium-4-(3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl)benzoate, HBC, Na, HAT Inhibitor VII, p300/CBP Inhibitor V, PCAF Inhibitor III
References
ReferencesArif, M., et al. 2010. Chem. Biol. 17, 903.
Shim, J.S., et al. 2004. Chem. Biol. 11, 1455.
Shim, J.S., et al. 2002. Bioorg. Med. Chem. Biol. 10, 2439.
Product Information
FormTan powder
Hill FormulaC₂₈H₂₃N₂NaO₆
Chemical formulaC₂₈H₂₃N₂NaO₆
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
382115-10MG 04055977213126

Documentation

Histone Acetyl Transferase Inhibitor VII, CTK7A - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Histone Acetyl Transferase Inhibitor VII, CTK7A - Calbiochem Certificates of Analysis

TitleLot Number
382115

References

Přehled odkazů
Arif, M., et al. 2010. Chem. Biol. 17, 903.
Shim, J.S., et al. 2004. Chem. Biol. 11, 1455.
Shim, J.S., et al. 2002. Bioorg. Med. Chem. Biol. 10, 2439.

Technical Info

Title
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-August-2012 JSW
SynonymsSodium-4-(3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl)benzoate, HBC, Na, HAT Inhibitor VII, p300/CBP Inhibitor V, PCAF Inhibitor III
DescriptionA cell-permeable and water soluble hydrazinobenzoylcurcumin (HBC) compound that acts as a selective, reversible and mixed mode inhibitor of p300/CBP and PCAF histone acetyltransferases (IC50 ≤ 25 and 50 µM, respectively) with minimal activity towards other histone modifying enzymes like, G9a, CARM1, HDAC1, SIRT2 and TIP60 (IC50 > 100 µM). Blocks the autoacetylation of p300 and PCAF and histone acetylation, downregulates cyclin E expression and induces senescence-like growth arrest at 100 µM in KB cells. Further, suppresses tumor growth in xenograft oral tumor nude mouse model (100 mg/kg, i.p., b.i.d.) and reduces H3K14 and H3K9 acetylation levels. Reported to potently inhibit bFGF-induced bovine aortic endothelial cells (BAECs) invasion and tube formation with an IC50 of 0.93 µM and binds to Ca2+/calmodulin with high-affinity (Kd = 8.11 µM) and antagonize its functions in HCT15 cells.
FormTan powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₈H₂₃N₂NaO₆
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesArif, M., et al. 2010. Chem. Biol. 17, 903.
Shim, J.S., et al. 2004. Chem. Biol. 11, 1455.
Shim, J.S., et al. 2002. Bioorg. Med. Chem. Biol. 10, 2439.