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377230 Hinokitiol

Hinokitiol MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-Isopropyltropolone, β-Thujaplicin

377230
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
499-44-5C₁₀H₁₂O₂
Description
OverviewA cell-permeable, anti-microbial tropolone analog that acts as an effective chelator of Fe3+/Fe2+, Zn2+, and Mg2+. Serves as a metalloprotease inhibitor. Also acts as a reversible inhibitor of 12-lipoxygenase in platelets (IC50 = 100 nM). Reported to strongly inhibit the active respiration in isolated rat liver mitochondria. Inhibits DNA synthesis, induces differentiation and apoptosis in F9 embryonal carcinoma cells.
Catalogue Number377230
Brand Family Calbiochem®
Synonyms4-Isopropyltropolone, β-Thujaplicin
References
ReferencesSuzuki, H., et al. 2000. Biochem. Biophys. Res. Commun. 275, 885. Tanaka, T., et al. 1999. Cell Biol. Int. 23, 541. Inamori, Y., et al. 1999. Biol. Pharm. Bull. 22, 990. Nakagawa, Y., and Tayama, K. 1998. Chem. Biol. Interact. 116, 45. Muto, N., et al. 1995. Biol. Pharm. Bull. 18, 1576. Bohme, G., et al. 1980. Acta. Biol. Med. Ger. 39, 1153.
Product Information
CAS number499-44-5
FormWhite solid
Hill FormulaC₁₀H₁₂O₂
Chemical formulaC₁₀H₁₂O₂
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Target12-lipoxygenase in platelets
Primary Target IC<sub>50</sub>100 nM
Purity≥99% by GC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSGU4200000
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage REFRIGERATOR (+4°C)
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°). DMSO stock solutions are stable for up to 2 months at -20°C; ethanol stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
377230 0

Documentation

Hinokitiol Certificates of Analysis

TitleLot Number
377230

References

Přehled odkazů
Suzuki, H., et al. 2000. Biochem. Biophys. Res. Commun. 275, 885. Tanaka, T., et al. 1999. Cell Biol. Int. 23, 541. Inamori, Y., et al. 1999. Biol. Pharm. Bull. 22, 990. Nakagawa, Y., and Tayama, K. 1998. Chem. Biol. Interact. 116, 45. Muto, N., et al. 1995. Biol. Pharm. Bull. 18, 1576. Bohme, G., et al. 1980. Acta. Biol. Med. Ger. 39, 1153.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-August-2007 JSW
Synonyms4-Isopropyltropolone, β-Thujaplicin
DescriptionA cell-permeable, tropolone analog that exhibits anti-microbial properties. Acts as an effective chelator of Fe3+/Fe2+, Zn2+, and Mg2+ and induces differentiation in F9 embryonal carcinoma cells. Serves as an inhibitor of metalloproteases and 12-lipoxygenase (12-LO) in platelets (IC50 = 100 nM). Shown to inhibit active respiration in isolated rat liver mitochondria. Also reported to inhibit DNA synthesis and induce apoptosis.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number499-44-5
RTECSGU4200000
Chemical formulaC₁₀H₁₂O₂
Structure formulaStructure formula
Purity≥99% by GC
SolubilityDMSO (20 mg/ml) or Ethanol (20 mg/ml)
Storage Protect from light
REFRIGERATOR (+4°C)
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°). DMSO stock solutions are stable for up to 2 months at -20°C; ethanol stock solutions are stable for up to 6 months at -20°C.
Toxicity Harmful
Merck USA index14, 9390
ReferencesSuzuki, H., et al. 2000. Biochem. Biophys. Res. Commun. 275, 885. Tanaka, T., et al. 1999. Cell Biol. Int. 23, 541. Inamori, Y., et al. 1999. Biol. Pharm. Bull. 22, 990. Nakagawa, Y., and Tayama, K. 1998. Chem. Biol. Interact. 116, 45. Muto, N., et al. 1995. Biol. Pharm. Bull. 18, 1576. Bohme, G., et al. 1980. Acta. Biol. Med. Ger. 39, 1153.