Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

400086 HIF Inhibitor VI - Calbiochem

The HIF-1 Inhibitor, NSC-134754 controls the biological activity of HIF-1. This small molecule/inhibitor is primarily used for Cell Structure applications.

HIF Inhibitor VI - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NSC-134754

400086
Purchase on Sigma-Aldrich

Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₂₇H₃₄N₂O₂

Products

Katalogové čísloBalení ks/bal.
400086-5MG Skleněná láhev 5 mg
Description
OverviewA cell-permeable emetan derivative that selectively reduces HIF-1 activity by 73% in a luciferase reporter assay, and blocks HIF-1α protein induction in response to DFX, hypoxia, and IGF-1 in U2OS-HRE-luc cells at 10 µM, without significantly inhibiting cell growth. Furthermore, it is shown to completely block HIF-1α induced by IGF-1 in HCT116 human colon carcinoma cells.
Catalogue Number400086
Brand Family Calbiochem®
SynonymsNSC-134754
References
ReferencesChau, N.M., et al. 2005. Cancer Res. 65, 4918.
Product Information
FormBrown solid
Hill FormulaC₂₇H₃₄N₂O₂
Chemical formulaC₂₇H₃₄N₂O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
400086-5MG 04055977212334

Documentation

HIF Inhibitor VI - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

HIF Inhibitor VI - Calbiochem Certificates of Analysis

TitleLot Number
400086

References

Přehled odkazů
Chau, N.M., et al. 2005. Cancer Res. 65, 4918.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-January-2013 JSW
SynonymsNSC-134754
DescriptionA cell-permeable emetan derivative that selectively reduces HIF-1 activity by 73% in a luciferase reporter assay, and blocks HIF-1α protein induction in response to DFX, hypoxia, and IGF-1 in U2OS-HRE-luc cells at 10 µM, without significantly inhibiting cell growth. Furthermore, it is shown to completely block HIF-1α induced by IGF-1 in HCT116 human colon carcinoma cells.
FormBrown solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₇H₃₄N₂O₂
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesChau, N.M., et al. 2005. Cancer Res. 65, 4918.