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372770 HBDDE - CAS 154675-18-0 - Calbiochem

A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKC&alpha and PKCγ over PKCδ, βI, and βII isozymes in in vitro assays.

HBDDE - CAS 154675-18-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2,2ʹ,3,3ʹ,4,4ʹ-Hexahydroxy-1,1ʹ-biphenyl-6,6ʹ-dimethanol Dimethyl Ether

Primary Target: PKCα
372770
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
154675-18-0C₁₆H₁₈O₈

Products

Katalogové čísloBalení ks/bal.
372770-1MG Plastová ampulka 1 mg
Description
OverviewA cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKCα (IC50 = 43 µM) and PKCγ (IC50 = 50 µM) over PKCδ, βI, and βII isozymes in in vitro assays. Reported to induce apoptosis in rodent cerebellar granule neurons.
Catalogue Number372770
Brand Family Calbiochem®
Synonyms2,2ʹ,3,3ʹ,4,4ʹ-Hexahydroxy-1,1ʹ-biphenyl-6,6ʹ-dimethanol Dimethyl Ether
References
ReferencesMathur, A., and Vallano, M.L. 2000. Biochem. Pharmacol. 60, 809.
Kashiwada, Y., et al. 1994. J. Med. Chem. 37, 195.
Product Information
CAS number154675-18-0
ATP CompetitiveN
FormOrange solid
Hill FormulaC₁₆H₁₈O₈
Chemical formulaC₁₆H₁₈O₈
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKCα
Primary Target IC<sub>50</sub>43 µM against PKCα
Purity≥95% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
372770-1MG 04055977212884

Documentation

HBDDE - CAS 154675-18-0 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

HBDDE - CAS 154675-18-0 - Calbiochem Certificates of Analysis

TitleLot Number
372770

References

Přehled odkazů
Mathur, A., and Vallano, M.L. 2000. Biochem. Pharmacol. 60, 809.
Kashiwada, Y., et al. 1994. J. Med. Chem. 37, 195.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-December-2018 JSW
Synonyms2,2ʹ,3,3ʹ,4,4ʹ-Hexahydroxy-1,1ʹ-biphenyl-6,6ʹ-dimethanol Dimethyl Ether
DescriptionProtein kinase C (PKC) inhibitor. Selectively inhibits PKCα (IC50 = 43 µM) and PKCγ (IC50 = 50 µM) over PKCδ, βI and βII isozymes.
FormOrange solid
CAS number154675-18-0
Chemical formulaC₁₆H₁₈O₈
Structure formulaStructure formula
Purity≥95% by TLC
SolubilityDMSO (5 mg/ml), Ethanol (1 mg/ml), or warm H₂O (1 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesMathur, A., and Vallano, M.L. 2000. Biochem. Pharmacol. 60, 809.
Kashiwada, Y., et al. 1994. J. Med. Chem. 37, 195.