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371545 Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem

G-protein-activating GTP analog, which is more resistant to hydrolysis than GTP.

Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: GTPγ-S, 4Li

Primary Target: G-protein-activating GTP analog
371545
  
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Tabulka spec. kláve

CAS #Empirical Formula
94825-44-2C₁₀H₁₂N₅O₁₃P₃S . 4Li
Description
OverviewG-protein-activating GTP analog, which is more resistant to hydrolysis than GTP. Induces exocytosis in isolated mouse pancreatic acinar cells. Also reported to stimulate insulin release from pancreatic β-cells.
Catalogue Number371545
Brand Family Calbiochem®
SynonymsGTPγ-S, 4Li
References
ReferencesIino, S., et al. 2000. FEBS Lett. 479, 46.
Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182.
Hess, S.D., et al. 1993. Science 259, 1169.
Ekstrom, R.C., et al. 1992. J. Biol. Chem. 267, 22183.
McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci. 49, 117.
Vaca, L., et al. 1992. Eur. J. Physiol. 422, 66.
Silk, S.T., et al. 1989. J. Biol. Chem. 264, 21466.
Gilman, A.G. 1987. Annu. Rev. Biochem. 56, 615.
Orellana, S., et al. 1987. J. Biol. Chem.. 262, 1638.
Product Information
CAS number94825-44-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₀H₁₂N₅O₁₃P₃S . 4Li
Chemical formulaC₁₀H₁₂N₅O₁₃P₃S . 4Li
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetG-protein-activating GTP analog
Purity≥85% by HPLC.
Physicochemical Information
Cell permeableN
ContaminantsGDP: ≤12%
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions lose about 5% of their activity after 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
371545 0

Documentation

Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem Certificates of Analysis

TitleLot Number
371545

References

Přehled odkazů
Iino, S., et al. 2000. FEBS Lett. 479, 46.
Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182.
Hess, S.D., et al. 1993. Science 259, 1169.
Ekstrom, R.C., et al. 1992. J. Biol. Chem. 267, 22183.
McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci. 49, 117.
Vaca, L., et al. 1992. Eur. J. Physiol. 422, 66.
Silk, S.T., et al. 1989. J. Biol. Chem. 264, 21466.
Gilman, A.G. 1987. Annu. Rev. Biochem. 56, 615.
Orellana, S., et al. 1987. J. Biol. Chem.. 262, 1638.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-June-2009 JSW
SynonymsGTPγ-S, 4Li
DescriptionG-protein-activating GTP analog that is more resistant to hydrolysis than GTP. Has a direct stimulatory effect on Ins(1,4,5)P3 formation in membranes.
FormWhite solid
CAS number94825-44-2
Chemical formulaC₁₀H₁₂N₅O₁₃P₃S . 4Li
Structure formulaStructure formula
Purity≥85% by HPLC.
ContaminantsGDP: ≤12%
SolubilityH₂O (10 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions lose about 5% of their activity after 6 months at -20°C.
Toxicity Standard Handling
ReferencesIino, S., et al. 2000. FEBS Lett. 479, 46.
Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182.
Hess, S.D., et al. 1993. Science 259, 1169.
Ekstrom, R.C., et al. 1992. J. Biol. Chem. 267, 22183.
McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci. 49, 117.
Vaca, L., et al. 1992. Eur. J. Physiol. 422, 66.
Silk, S.T., et al. 1989. J. Biol. Chem. 264, 21466.
Gilman, A.G. 1987. Annu. Rev. Biochem. 56, 615.
Orellana, S., et al. 1987. J. Biol. Chem.. 262, 1638.