Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

344085 Folimycin, Streptomyces sp. - CAS 80890-47-7 - Calbiochem

A highly sensitive and specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 20 pM).

Folimycin, Streptomyces sp. - CAS 80890-47-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Concanamycin A

Primary Target: Vacuolar-type H+-ATPase
344085
  
Purchase on Sigma-Aldrich

Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
80890-47-7C₄₆H₇₅NO₁₄
Description
OverviewA highly sensitive and specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 20 pM). Inhibits acidification of organelles, such as lysosomes and the Golgi apparatus. Also blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. Useful for studies of intracellular protein translocation. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay.
Catalogue Number344085
Brand Family Calbiochem®
SynonymsConcanamycin A
References
ReferencesKane, M.D., et al. 1999. J. Neurochem. 72, 1939.
Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 212, 255.
Muroi, M., et al. 1994. Biosci. Biotech. Biochem. 58, 425.
Drose, S., et al. 1993. Biochemistry 32, 3902.
Muroi, M., et al. 1993. Biochem. Biophys. Res. Commun. 193, 999.
Muroi, M., et al. 1993. Cell Struct. Funct. 18, 139.
Product Information
CAS number80890-47-7
ATP CompetitiveN
FormLyophilized solid
Hill FormulaC₄₆H₇₅NO₁₄
Chemical formulaC₄₆H₇₅NO₁₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetVacuolar-type H+-ATPase
Primary Target K<sub>i</sub>20 pM against vacuolar-type H+-ATPase
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSLP5970000
Safety Information
R PhraseR: 28-37

Very toxic if swallowed.
Irritating to respiratory system.
S PhraseS: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
344085 0

Documentation

Folimycin, Streptomyces sp. - CAS 80890-47-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Folimycin, Streptomyces sp. - CAS 80890-47-7 - Calbiochem Certificates of Analysis

TitleLot Number
344085

References

Přehled odkazů
Kane, M.D., et al. 1999. J. Neurochem. 72, 1939.
Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 212, 255.
Muroi, M., et al. 1994. Biosci. Biotech. Biochem. 58, 425.
Drose, S., et al. 1993. Biochemistry 32, 3902.
Muroi, M., et al. 1993. Biochem. Biophys. Res. Commun. 193, 999.
Muroi, M., et al. 1993. Cell Struct. Funct. 18, 139.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-June-2008 RFH
SynonymsConcanamycin A
DescriptionA highly sensitive and specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 20 pM). Inhibits acidification of organelles, such as lysosomes and the Golgi apparatus. Also blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. Useful for studies of intracellular protein translocation. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay.
FormLyophilized solid
CAS number80890-47-7
RTECSLP5970000
Chemical formulaC₄₆H₇₅NO₁₄
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO. Further dilute with aqueous buffers just prior to use.
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
Toxicity Highly Toxic
ReferencesKane, M.D., et al. 1999. J. Neurochem. 72, 1939.
Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 212, 255.
Muroi, M., et al. 1994. Biosci. Biotech. Biochem. 58, 425.
Drose, S., et al. 1993. Biochemistry 32, 3902.
Muroi, M., et al. 1993. Biochem. Biophys. Res. Commun. 193, 999.
Muroi, M., et al. 1993. Cell Struct. Funct. 18, 139.