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324631 Eg5 Inhibitor VII - CAS 912953-25-4 - Calbiochem

The Eg5 Inhibitor VII, also referenced under CAS 912953-25-4, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications.

Eg5 Inhibitor VII - CAS 912953-25-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: KSP Inhibitor VII; 6-(4-Trifluoromethyl)phenyl)-3,4-dihydro-2(1H)-quinolinone, GSK-1

324631
  
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
912953-25-4C₁₆H₁₂F₃NO
Description
Overview

This product has been discontinued.



A cell-permeable quinolinone compound that acts as a highly potent and selective Eg5/KSP inhibitor (Ki = 1.4, 2.1, 2.2, and 1.7 nM for the mutant A133D, KHC-L5, D130V, and the wild-type KSP, respectively) by antagonizing ATP binding via an allosteric site. Effectively induces monopolar spindles in ovarian adenocarcinoma SKOV3 cells and inhibits the proliferation of colorectal carcinoma HCT116 cells (IC50 = 36 and 0.5 nM againt the parental and the ispinesib-resistant D130V mutant line, respectively). It is uncompetitive with respect to microtubule and exhibits little activity against a panel of 7 other mitotic kinesins.
Catalogue Number324631
Brand Family Calbiochem®
SynonymsKSP Inhibitor VII; 6-(4-Trifluoromethyl)phenyl)-3,4-dihydro-2(1H)-quinolinone, GSK-1
References
ReferencesLuo, L., et al. 2007. Nat. Chem. Biol. 3, 722.
Product Information
CAS number912953-25-4
FormOff-white powder
Hill FormulaC₁₆H₁₂F₃NO
Chemical formulaC₁₆H₁₂F₃NO
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
324631 0

Documentation

Eg5 Inhibitor VII - CAS 912953-25-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Eg5 Inhibitor VII - CAS 912953-25-4 - Calbiochem Certificates of Analysis

TitleLot Number
324631

References

Přehled odkazů
Luo, L., et al. 2007. Nat. Chem. Biol. 3, 722.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2011 RFH
SynonymsKSP Inhibitor VII; 6-(4-Trifluoromethyl)phenyl)-3,4-dihydro-2(1H)-quinolinone, GSK-1
DescriptionA cell-permeable quinolinone compound that acts as a highly potent and selective Eg5/KSP inhibitor (Ki = 1.4, 2.1, 2.2, and 1.7 nM for the mutant A133D, KHC-L5, D130V, and the wild-type KSP, respectively) by antagonizing ATP binding via an allosteric site. Effectively induces monopolar spindles in ovarian adenocarcinoma SKOV3 cells and inhibits the proliferation of colorectal carcinoma HCT116 cells (IC50 = 36 and 0.5 nM againt the parental and the ispinesib-resistant D130V mutant line, respectively). It is uncompetitive with respect to microtubule and exhibits little activity against a panel of 7 other mitotic kinesins.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number912953-25-4
Chemical formulaC₁₆H₁₂F₃NO
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesLuo, L., et al. 2007. Nat. Chem. Biol. 3, 722.