260960 Sigma-AldrichDNA-PK Inhibitor - CAS 20357-25-9 - Calbiochem
The DNA-PK Inhibitor, also referenced under CAS 20357-25-9, controls the biological activity of DNA-PK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The DNA-PK Inhibitor, also referenced under CAS 20357-25-9, controls the biological activity of DNA-PK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<DNA-PK Inhibitor - CAS 20357-25-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: DMNB, 4,5-Dimethoxy-2-nitrobenzaldehyde, DNA-Dependent Protein Kinase Inhibitor
Recommended Products
Přehled
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Tabulka spec. kláve
| CAS # | Empirical Formula |
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| 20357-25-9 | C₉H₉NO₅ |
Products
| Katalogové číslo | Balení | ks/bal. | |
|---|---|---|---|
| 260960-10MG | Plastová ampulka | 10 mg |
| Description | |
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| Overview | A cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-PK (DNA-dependent protein kinase) activity (IC50 = 15 µM) and DNA-PK-mediated DSB (double strand break) DNA repair by NHEJ (non-homologous DNA-end-joining). Shown to effectively sensitize cells to killing by Cisplatin (Cat. No. 232120). Does not affect PKC or Chk2 kinase activities. |
| Catalogue Number | 260960 |
| Brand Family | Calbiochem® |
| Synonyms | DMNB, 4,5-Dimethoxy-2-nitrobenzaldehyde, DNA-Dependent Protein Kinase Inhibitor |
| References | |
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| References | Willmore, E., et al. 2004. Blood,103, 4659. Durant, S., and Karran, P. 2003. Nucleic Acids Res. 31, 5501. |
| Product Information | |
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| CAS number | 20357-25-9 |
| ATP Competitive | N |
| Form | Bright Yellow solid |
| Hill Formula | C₉H₉NO₅ |
| Chemical formula | C₉H₉NO₅ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | DNA-PK activity |
| Primary Target IC<sub>50</sub> | 15 µM against DNA-PK (DNA-dependent protein kinase) activity |
| Purity | ≥90% by GC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Katalogové číslo | GTIN |
| 260960-10MG | 04055977217544 |
Documentation
DNA-PK Inhibitor - CAS 20357-25-9 - Calbiochem MSDS
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DNA-PK Inhibitor - CAS 20357-25-9 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 260960 |
References
| Přehled odkazů |
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| Willmore, E., et al. 2004. Blood,103, 4659. Durant, S., and Karran, P. 2003. Nucleic Acids Res. 31, 5501. |