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217714 Cdk1/2 Inhibitor III - CAS 443798-55-8 - Calbiochem

The Cdk1/2 Inhibitor III, also referenced under CAS 443798-55-8, controls the biological activity of Cdk1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation

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Cdk1/2 Inhibitor III - CAS 443798-55-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide

Primary Target: Cdk1/cyclin B, Cdk2/cyclin A
217714
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Tabulka spec. kláve

CAS #Empirical Formula
443798-55-8C₁₅H₁₃F₂N₇O₂S₂

Products

Katalogové čísloBalení ks/bal.
217714-1MG Plastová ampulka 1 mg
Přidat k oblíbeným položkám
Description
OverviewA cell-permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa, and A375 cells, respectively). Acts as a highly potent, reversible, ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50 = 600 pM and 500 pM, respectively) with selectivity over VEGF-R2 (IC50 = 32 nM), GSK-3β (IC50 = 140 nM), and a panel of eight other kinases (IC50 ≥ 1 µM).
Catalogue Number217714
Brand Family Calbiochem®
Synonyms5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
References
ReferencesLin, R., et al. 2005.J. Med. Chem. 48, 4208.
Product Information
CAS number443798-55-8
ATP CompetitiveY
FormWhite solid
Hill FormulaC₁₅H₁₃F₂N₇O₂S₂
Chemical formulaC₁₅H₁₃F₂N₇O₂S₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetCdk1/cyclin B, Cdk2/cyclin A
Primary Target IC<sub>50</sub>20 nM, 35 nM and 92 nM for anti-proliferative properties in HCT-116, HeLa, and A375 cells, respectively; 600 pM and 500 pM, against Cdk1/cyclin B and Cdk2/cyclin A, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
217714-1MG 04055977202397