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688225 Caspase-1 Substrate VI, Fluorogenic - CAS 219137-85-6 - Calbiochem

Fluorogenic caspase-1 substrate.

Caspase-1 Substrate VI, Fluorogenic - CAS 219137-85-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-YVAD-AFC

688225
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Přehled

Replacement Information

Products

Katalogové čísloBalení ks/bal.
688225-5MG Plastová ampulka 5 mg
Description
OverviewFluorogenic caspase-1 substrate. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.
Catalogue Number688225
Brand Family Calbiochem®
SynonymsZ-YVAD-AFC
References
ReferencesJones, R.A., et al. 1998. Hepatology 27, 1632.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Walker, N.P., et al. 1994. Cell 78, 343.
Thornberry, N.A., et al. 1992. Nature 356, 768.
Product Information
CAS number219137-85-6
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₃₃H₃₆F₃N₅O₁₀
Chemical formulaC₃₃H₃₆F₃N₅O₁₀
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetFluorogenic caspase-1 substrate
Purity98±1% by HPLC
Physicochemical Information
Cell permeableN
Emission max.
Excitation max.
Peptide SequenceAc-Tyr-Val-Ala-Asp-AFC
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
688225-5MG 04055977225488

Documentation

Caspase-1 Substrate VI, Fluorogenic - CAS 219137-85-6 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Caspase-1 Substrate VI, Fluorogenic - CAS 219137-85-6 - Calbiochem Certificates of Analysis

TitleLot Number
688225

References

Přehled odkazů
Jones, R.A., et al. 1998. Hepatology 27, 1632.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Walker, N.P., et al. 1994. Cell 78, 343.
Thornberry, N.A., et al. 1992. Nature 356, 768.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-April-2011 RFH
SynonymsZ-YVAD-AFC
DescriptionFluorogenic ICE substrate. Reaction can be monitored by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore. AFC (7-amino-4-trifluoromethylcoumarin) based fluorometric substrates are superior to AMC (7-amino-4-methylcoumarin) substrates because released AFC has a greater Stoke's shift than AMC. Excitation/emission maxima (nm) for AFC and AMC are 400/505 and 380/460, respectively.
FormWhite to off-white solid
CAS number219137-85-6
Chemical formulaC₃₃H₃₆F₃N₅O₁₀
Peptide SequenceAc-Tyr-Val-Ala-Asp-AFC
Structure formulaStructure formula
Purity98±1% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from moisture
Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesJones, R.A., et al. 1998. Hepatology 27, 1632.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Walker, N.P., et al. 1994. Cell 78, 343.
Thornberry, N.A., et al. 1992. Nature 356, 768.