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219671 CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem

CFTR Inhibitor II, GlyH-101, CAS 328541-79-3, is a cell-permeable potent, selective and reversible open-channel blocker of CFTR (Ki = 4.3 µM in CFTR-expressing FRT cells).

CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide

Primary Target: CFTR
219671
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Přehled

Replacement Information

Tabulka spec. kláve

CAS #Empirical Formula
328541-79-3C₁₉H₁₅Br₂N₃O₃

Products

Katalogové čísloBalení ks/bal.
219671-5MG Plastová ampulka 5 mg
Description
OverviewA cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo. Also available as a 25 mM solution in DMSO (Cat. No. 219675).
Catalogue Number219671
Brand Family Calbiochem®
SynonymsN-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide
References
ReferencesSonawane, N.D., et al. 2006. FASEB J. 20, 130.
Muanprasat, C., et al. 2004. J. Gen. Physiol. 124, 125.
Product Information
CAS number328541-79-3
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₉H₁₅Br₂N₃O₃
Chemical formulaC₁₉H₁₅Br₂N₃O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCFTR
Primary Target IC<sub>50</sub>95% inhibition at 50 µM
Primary Target K<sub>i</sub>4.3 µM in CFTR-expressing FRT cells for apical membrane Cl- current
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
219671-5MG 07790788048747

Documentation

CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem Certificates of Analysis

TitleLot Number
219671

References

Přehled odkazů
Sonawane, N.D., et al. 2006. FASEB J. 20, 130.
Muanprasat, C., et al. 2004. J. Gen. Physiol. 124, 125.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
SynonymsN-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide
DescriptionA cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo.
FormYellow solid
CAS number328541-79-3
Chemical formulaC₁₉H₁₅Br₂N₃O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (200 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSonawane, N.D., et al. 2006. FASEB J. 20, 130.
Muanprasat, C., et al. 2004. J. Gen. Physiol. 124, 125.