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SCT039 BioTracker Green H2O2 Live Cell Dye

Live cell imaging probe for detection of hydrogen peroxide (H2O2) in live cells.

SCT039
3 x 30 nmol  
Purchase on Sigma-Aldrich

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Replacement Information
Description
Catalogue NumberSCT039
DescriptionBioTracker Green H2O2 Live Cell Dye
OverviewHydrogen peroxide (H2O2) is involved in therapeutic processes such as wound healing, anti-bacterial defense, stem cell proliferation, and an adaptive response in astrocytes that leads to neuronal protection. However, over-production of H2O2 exerts toxic effects on the cell and its surrounding environment. Over-production of H2O2 is connected to serious pathological conditions such as cancer, ageing, diabetes, and neurodegenerative diseases.

BioTracker Green H2O2 live cell dye is a fluorescent probe that fluoresces upon reaction with H2O2 , but does not react with other ROS such as hydroxyradical (-OH), superoxide (O2－), hypochlorous acid (HOCl), singlet oxygen (1O2), and nitric oxide (NO). This dye is cell permeable and initially has low reactivity with H2O2 but it is quickly hydrolyzed by intracellular esterases to generate a reactive and cell impermeable product that fluoresces upon reaction with H2O2.

Spectral Properties
Absorbance (max): 492 nm
Emission (max): 516 nm (Green)

References
Abo M et al. Development of a Highly Sensitive Fluorescence Probe for Hydrogen Peroxide. J. Am. Chem. Soc. 2011. 133, 27, 10629-10637.
Alternate Names
  • HYDROP™
References
Product Information
Detection methodFluorescence
PresentationLyophilized
Applications
ApplicationLive cell imaging probe for detection of hydrogen peroxide (H2O2) in live cells.
Key Applications
  • Cell Based Assays
Application NotesLive cell fluorescent imaging. Green fluorescence.
Biological Information
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssurancePurity: ≥ 90% (LC)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore BioTracker Green H2O2 Live Cell Dye at -20°C, desiccate and protect from light
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
Packaging Information
Material Size3 x 30 nmol
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
SCT039 04061841588252