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189485 Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable - Calbiochem

Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable, is a specific, potent inhibitor of CaMKII. Contains the Antennapedia transport peptide fused to the amino terminus of AIP-II.

Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ant-A3K/V10F-AIP, Ant-AIP-II, Ac-RQIKIWFQNRRMKWKKKKKLRRQEAFDAL-OH

Primary Target: cam Kinase-2
189485
Purchase on Sigma-Aldrich

Přehled

Replacement Information

Tabulka spec. kláve

Empirical Formula
C₁₇₇H₂₉₁N₅₇O₃₉S

Products

Katalogové čísloBalení ks/bal.
189485-1MG Plastová ampulka 1 mg
Description
OverviewA highly specific, potent, cell-permeable calmodulin-dependent protein kinase II (CaMKII) inhibitor that contains the Antennapedia transport peptide sequence fused to the amino terminus of AIP-II (Cat. No. 189484).
Catalogue Number189485
Brand Family Calbiochem®
SynonymsAnt-A3K/V10F-AIP, Ant-AIP-II, Ac-RQIKIWFQNRRMKWKKKKKLRRQEAFDAL-OH
References
ReferencesWatterson, D.M., et al. 2001. Neurochem. Int. 39, 459.
Ishida, A., et al. 1998. FEBS Lett. 427, 115.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₇₇H₂₉₁N₅₇O₃₉S
Chemical formulaC₁₇₇H₂₉₁N₅₇O₃₉S
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ200
Applications
ApplicationAutocamtide-2 Related Inhibitory Peptide II, Cell-permeable, is a specific, potent inhibitor of CaMKII. Contains the Antennapedia transport peptide fused to the amino terminus of AIP-II.
Biological Information
Primary Targetcam Kinase-2
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceAc-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
189485-1MG 04055977221800

Documentation

Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable - Calbiochem Certificates of Analysis

TitleLot Number
189485

References

Přehled odkazů
Watterson, D.M., et al. 2001. Neurochem. Int. 39, 459.
Ishida, A., et al. 1998. FEBS Lett. 427, 115.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-April-2008 RFH
SynonymsAnt-A3K/V10F-AIP, Ant-AIP-II, Ac-RQIKIWFQNRRMKWKKKKKLRRQEAFDAL-OH
DescriptionA highly specific, potent, cell-permeable calmodulin-dependent protein kinase II (CaMKII) inhibitory peptide that contains the Antennapedia transport peptide sequence fused to the N-terminus of autocamtide inhibitory peptide-II (AIP-II) (Cat. No. 189484). AIP-II is an AIP analog where Ala3 and Val10 are replaced by Lys and Phe residues. AIP-II is reported to be more potent than CaMK-(281-302/Ala286) and KN-93 (Cat. No. 422708). Inhibits by binding to the autophosphorylation site, which is distinct from the exogenous substrate-binding site.
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₇₇H₂₉₁N₅₇O₃₉S
Peptide SequenceAc-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml), H₂O (1 mg/ml), or 5% Acetic Acid (1 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity Standard Handling
ReferencesWatterson, D.M., et al. 2001. Neurochem. Int. 39, 459.
Ishida, A., et al. 1998. FEBS Lett. 427, 115.