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189410 Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem

189410
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Tabulka spec. kláve

CAS #Empirical Formula
331771-20-1C₂₉H₃₁N₅O₄

Products

Katalogové čísloBalení ks/bal.
189410-5MG Skleněná láhev 5 mg
Description
OverviewA cell-permeable quinazoline compound that targets the ATP binding pocket and an adjacent cleft and acts as a potent and reversible inhibitor of Aurora A and Aurora B (IC50 = 110 and 130 nM, respectively) with moderate to excellent selectivity among closely related 16-kinase panel (IC50 = 0.88, 1.03 and 1.79 µM for Lck, Src and MEK1, respectively, and IC50 > 10 µM for Cdk1/2/4, Plk1, Chk1). Blocks phosphorylation of Histone H3-Ser10 in Xenopus cycling egg extracts at 20 µM, and reduces mitotic spindle assembly. Shown to repress kinetochore localization of BubR1, Cenp-E, and Mad2, and arrest the growth of proliferating tumor cells.
Catalogue Number189410
Brand Family Calbiochem®
Synonyms4-(4-(N-Benzoylamino)anilino)-6- methoxy-7-(3-(1-morpholino)propoxy)quinazoline
References
ReferencesGadea, B.B. and Ruderman, J.V., 2005. Mol. Biol. Cell 16, 1305.
Ditchfield, C., et al. 2003. J. Cell Biol. 161, 267.
Product Information
CAS number331771-20-1
FormWhite solid
Hill FormulaC₂₉H₃₁N₅O₄
Chemical formulaC₂₉H₃₁N₅O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥95% by HPLC
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalogové číslo GTIN
189410-5MG 04055977221763