Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

ABS449 Anti-UNG1 Antibody

Anti-UNG1 Antibody is a highly specific rabbit polyclonal antibody, that targets Uracil-DNA glycosylase 1 & has been tested in western blotting & IHC.

Anti-UNG1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Developmental Signaling Gene Symbol: UNG, DGU, UNG1, UNG15 UniProt Number: P13051
ABS449
100 µg  
Purchase on Sigma-Aldrich

Speciální nabídky

Přehled

Replacement Information

Speciální nabídky

100% Performance Guaranteed

Tabulka spec. kláve

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABS449
DescriptionAnti-UNG1 Antibody
Alternate Names
  • Uracil-DNA glycosylase 1
  • UDG1
Background InformationUracil-DNA glycosylase 1 (UNG1), also known as UDG1, DGU or UNG15, hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, and as a result it releases free uracil. UNG1 excises uracil residues from the DNA. This event could be a result of faulty incorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Uniport describes two isoforms. The fist isoform is widely expressed with the highest expression in skeletal muscle, heart and testicles. The second isoform has the highest expression levels in tissues containing proliferating cells. Recent studies have shown that defects in UNG are a cause of immunodeficiency with hyper-IgM type 5 (HIGM5). HIGM5 is a rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections.
References
Product Information
FormatAffinity Purified
Control
  • C2C12 cell lysate
PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-UNG1 Antibody is a highly specific rabbit polyclonal antibody, that targets Uracil-DNA glycosylase 1 & has been tested in western blotting & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: 2 µg/mL from a representative lot detected UNG1 in human heart tissue.

Immunofluorescence Analysis: 20 µg/mL from a representative lot detected UNG1 in human heart tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of human UNG1.
EpitopeC-terminus
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes the C-terminus of UNG1.
Species Reactivity
  • Human
  • Mouse
Antibody TypePolyclonal Antibody
Gene Symbol
  • UNG
  • DGU
  • UNG1
  • UNG15
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~37 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 2 isoforms at ~34 kDa and ~35 kDa.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in C2C12 cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected UNG1 in 15 µg of C2C12 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
ABS449 04053252910180