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MABE430 Anti-TIP60 Antibody, clone 3F9

Anti-TIP60 Antibody, clone 3F9 is a highly specific mouse monoclonal antibody, that targets Tip60 & has been tested in western blotting & IHC.

Anti-TIP60 Antibody, clone 3F9 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: TIP60, KAT5, HTATIP UniProt Number: P63279
MABE430
100 µL  
Purchase on Sigma-Aldrich

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Speciální nabídky

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Tabulka spec. kláve

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHCMAscitesMonoclonal Antibody
Description
Catalogue NumberMABE430
DescriptionAnti-TIP60 Antibody, clone 3F9
Alternate Names
  • Histone acetyltransferase KAT5
  • 60 kDa Tat-interactive protein
  • Tip60
  • Histone acetyltransferase HTATIP
  • HIV-1 Tat interactive protein
  • Lysine acetyltransferase 5
  • cPLA(2)-interacting protein
Background InformationTIP60 protein or also known as Histone acetyltransferase KAT5, 60kDa Tat-interactive protein, Histone acetyltransferase HTATIP, HIV-1 Tat interactive protein, Lysine acetyltransferase 5, or cPLA(2)-interacting protein and encoded by the KAT5/HTATIP/TIP60 gene is a histone acetyl transferase that forms the catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of a number of genes via the acetylation of histone H4 and H2A. TIP60 plays a role in DNA repair, growth arrest and senescence, apoptosis, chromatin remodeling, and tumor suppression. First discovered as protein that interacted with HIV-1 Tat resulting in TIP60 becoming polyubiquitinated and degraded (which prevented apoptosis of the infected cell), TIP60 is now known to interact with a number of other intracellular proteins including HDAC7A, CREB1, BCL3, Androgen receptor and PLA2G4A. TIP60 is largely localized to the nucleus or nuclear envelope in most tissues. TIP60 is also necessary for oncogene and proto-oncogene mediated growth induction seen in many cancers. EMD-Millipore’s Anti-TIP60 mouse monoclonal antibody has been tested in western blot on recombinant TIP60 protein and in paraffin embedded immunohistochemistry on human liver carcinoma, rectum carcinoma, normal medulla and normal interbrain tissue sections.
References
Product Information
FormatAscites
Control
  • Human recombinant TIP60 protein
PresentationMouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-TIP60 Antibody, clone 3F9 is a highly specific mouse monoclonal antibody, that targets Tip60 & has been tested in western blotting & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected TIP60 in liver carcinoma, rectum carcinoma, normal medulla and interbrain tissues.

Optimal working dilutions must be determined by end user.
Biological Information
ImmunogenPurified recombinant fragment of human TIP60 expressed in E. Coli.
Clone3F9
HostMouse
IsotypeIgG2b
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Gene Symbol
  • TIP60
  • KAT5
  • HTATIP
Purification MethodUnpurified
UniProt Number
Molecular Weight~60 kDa observed. Uncharacterized bands may appear in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human recombinant TIP60 protein.

Western Blotting Analysis: A 1:500-2,000 dilution of this antibody detected human recombinant TIP60 protein.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
MABE430 04053252920530

Documentation

Anti-TIP60 Antibody, clone 3F9 MSDS

Title

Safety Data Sheet (SDS) 

Anti-TIP60 Antibody, clone 3F9 Certificates of Analysis

TitleLot Number
Anti-TIP60, clone 3F9 - QVP1306171 QVP1306171
Anti-TIP60, clone 3F9 - VP1912132 VP1912132
Anti-TIP60, clone 3F9 -VP1410075 VP1410075
Anti-TIP60, clone 3F9 -VP1602243 VP1602243
Anti-TIP60, clone 3F9 -VP1604190 VP1604190
Anti-TIP60, clone 3F9 -VP1611236 VP1611236
Anti-TIP60, clone 3F9 Monoclonal Antibody VP1712292
Anti-TIP60, clone 3F9 Monoclonal Antibody VP1708213