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07-1813 Anti-Septin-2 Antibody

Use Anti-Septin-2 Antibody (Rabbit Polyclonal Antibody) validated in WB, IF to detect Septin-2 also known as Neural precursor cell expressed developmentally down-regulated protein 5, septin 2.

Anti-Septin-2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Cell Cycle, DNA Replication & Repair, Cell Cycle, DNA Replication & Repair Gene Symbol: SEPT2, DIFF6, NEDD-5, NEDD5, Pnutl3, hNedd5 UniProt Number: Q15019
07-1813
100 µL  
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Tabulka spec. kláve

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWB, IFRbSerumPolyclonal Antibody
Description
Catalogue Number07-1813
DescriptionAnti-Septin-2 Antibody
Alternate Names
  • Neural precursor cell expressed developmentally down-regulated protein 5
  • neural precursor cell expressed, developmentally down-regulated 5
  • septin 2
Background InformationSeptin-2 belongs to the septin family of GTPases. Originally characterized as regulators of cytokinesis, septins were later implicated in other cellular processes. Recent studies show that septins have a broader role in microtubule-dependent processes, such as karyokinesis, exocytosis, and maintenance of cell shape. Many members of the septin family have been shown to colocalize or interact with the microtubule cytoskeleton, suggesting that these might be general properties of septins. Septin-2 is expressed in the brain and may be associated with Alzheimer's disease.
References
Product Information
FormatSerum
Control
  • Hek293 cell lysate
PresentationUnpurified rabbit polyclonal with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationUse Anti-Septin-2 Antibody (Rabbit Polyclonal Antibody) validated in WB, IF to detect Septin-2 also known as Neural precursor cell expressed developmentally down-regulated protein 5, septin 2.
Key Applications
  • Western Blotting
  • Immunofluorescence
Application NotesImmunofluorescence: Reported by external laboratory using representative lot.
Biological Information
ImmunogenHis-tagged recombinant protein corresponding to human Septin-2.
EpitopeUnknown
HostRabbit
SpecificityThis antibody recognizes Septin-2.
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity NoteProven to react with human, mouse, and rat.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • SEPT2
  • DIFF6
  • NEDD-5
  • NEDD5
  • Pnutl3
  • hNedd5
Purification MethodUnpurified
UniProt Number
UniProt SummaryFUNCTION: Required for normal progress through mitosis. Involved in cytokinesis.

SUBUNIT STRUCTURE: Monomer, and homodimer. Nucleotide binding promotes dimerization. Heterohexamer composed of two heterotrimers containing one copy each of SEPT2, SEPT6 and SEPT7. The asymmetrical heterotrimers associate head-to-head to form a hexameric unit that assembles into filaments.

SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm › cytoskeleton › spindle. Note: Accumulates near the contractile ring from anaphase through telophase, and finally condenses into the midbody. In interphase and postmitotic cells, localized to fibrous or granular structures, depending on the growth state of the cell By similarity.

SEQUENCE SIMLARITIES: Belongs to the septin family.
Molecular Weight 41 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in Hek293 cell lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected Septin-2 on 10 µg of Hek293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
07-1813 04053252511707