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AB15115 Anti-NARC-1 Antibody

NARC-1 is an antibody targeting the NARC-1 protein, validated for use in WB.

Anti-NARC-1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: PCSK9, NARC1, NARC-1, FH3, HCHOLA3 UniProt Number: Q8NBP7
AB15115
100 µL  
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Tabulka spec. kláve

Species ReactivityKey ApplicationsHostFormatAntibody Type
MWBRbSerumPolyclonal Antibody
Description
Catalogue NumberAB15115
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-NARC-1 Antibody
Alternate Names
  • Neural Apoptosis-Regulated Convertase 1
  • PCSK9
References
Product Information
FormatSerum
PresentationRabbit serum.
Quality LevelMQ100
Applications
ApplicationNARC-1 is an antibody targeting the NARC-1 protein, validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
ImmunogenSynthetic peptide.
HostRabbit
SpecificityNeural apoptosis-regulated convertase 1 [NARC-1, Pcsk9]. By Western blot the antibody recognizes a doublet at ~76 kDa in mouse liver lysate.
Species Reactivity
  • Mouse
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
Gene Symbol
  • PCSK9
  • NARC1
  • NARC-1
  • FH3
  • HCHOLA3
Purification MethodSerum
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q8NBP7 # May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.
COFACTOR: Calcium (Probable).
SIZE: 692 amino acids; 74372 Da
SUBUNIT: The precursor protein but not the mature protein may form multimers.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
PTM: The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.
DISEASE:SwissProt: Q8NBP7 # Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.
SIMILARITY: SwissProt: Q8NBP7 ## Belongs to the peptidase S8 family. & Contains 1 peptidase S8 domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20degC in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalogové číslo GTIN
AB15115 04053252282270